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Sigle :<\/strong> SGCSR Directeur :<\/strong> St\u00e9phane MARCAND (stephane.marcand@cea.fr<\/a>) L’Unit\u00e9 Mixte de Recherche \u00ab Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations \u00bb (SGCSR) consacre ses recherches aux m\u00e9canismes mol\u00e9culaires assurant la r\u00e9paration des dommages de l’ADN et la stabilit\u00e9 du g\u00e9nome, ainsi qu’aux cellules souches normales et canc\u00e9reuses (germinales, h\u00e9matopo\u00ef\u00e9tiques, \u00e9pidermiques et neurales). La combinaison de ces deux th\u00e9matiques permet aux \u00e9quipes de l’UMR de d\u00e9velopper une recherche originale sur la caract\u00e9risation des r\u00e9ponses cellulaires et tissulaires aux stress g\u00e9notoxiques notamment li\u00e9s \u00e0 l’exposition aux radiations ionisantes. Pour cela, elles font appel \u00e0 diff\u00e9rents syst\u00e8mes mod\u00e8les (Saccharomyces cerevisiae, Helicobacter pylori), des cultures 2D et 3D de cellules primaires ou de lign\u00e9es cellulaires (humaines ou murines) ainsi que des mod\u00e8les pr\u00e9cliniques (souris). L’objectif g\u00e9n\u00e9ral est de permettre une meilleure compr\u00e9hension du d\u00e9veloppement de diff\u00e9rentes pathologies canc\u00e9reuses et non-canc\u00e9reuses, afin de proposer de nouvelles strat\u00e9gies pr\u00e9ventives et\/ou th\u00e9rapeutiques sp\u00e9cifiques.<\/p>\n https:\/\/jacob.cea.fr\/drf\/ifrancoisjacob\/Pages\/Departements\/IRCM\/Productions.aspx<\/a><\/p>\n \u00a0<\/strong><\/p>\n Cellule ing\u00e9nierie g\u00e9n\u00e9tique et d\u2019expression (CIGEx)\u00a0: didier.busso@cea.fr<\/a> UMR SGCSR https:\/\/www.cea.fr\/drf\/ifrancoisjacob\/Pages\/Departements\/IRCM\/UMR-SGCSR.aspx\u00a0<\/a><\/p>\n <\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb3.22″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2″ _builder_version=\u00a0\u00bb3.0.47″][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2″ _builder_version=\u00a0\u00bb3.0.47″][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Sigle : SGCSRTutelles : Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris-Saclay, Inserm, CEAUFR de rattachement : Sciences du VivantLabel unit\u00e9 : UMRE008-U1274 Directeur : St\u00e9phane MARCAND (stephane.marcand@cea.fr)Directrice adjointe : Fran\u00e7oise PFLUMIO (francoise.pflumio@cea.fr)Responsable administrative : Aur\u00e9lie GOURET (secretariat-u1274@cea.fr) Pr\u00e9sentation\u00a0: L’Unit\u00e9 Mixte de Recherche \u00ab Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations \u00bb (SGCSR) consacre ses recherches aux m\u00e9canismes mol\u00e9culaires… Lire la suite Stabilit\u00e9 g\u00e9n\u00e9tique, cellules souches et radiations<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"coauthors":[17],"class_list":["post-1585","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/comments?post=1585"}],"version-history":[{"count":17,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1585\/revisions"}],"predecessor-version":[{"id":5493,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1585\/revisions\/5493"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/media?parent=1585"}],"wp:term":[{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/coauthors?post=1585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Tutelles :<\/strong> Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris-Saclay, Inserm, CEA
UFR de rattachement :<\/strong> Sciences du Vivant
Label unit\u00e9 :<\/strong> UMRE008-U1274<\/p>\n
Directrice adjointe :<\/strong> Fran\u00e7oise PFLUMIO (francoise.pflumio@cea.fr<\/a>)
Responsable administrative :<\/strong> Aur\u00e9lie GOURET (secretariat-u1274@cea.fr<\/a>)<\/p>\nPr\u00e9sentation<\/strong>\u00a0:<\/h3>\n
Listes des Publications\u00a0:<\/strong><\/h3>\n
Equipes de recherche\u00a0:<\/strong><\/h3>\n
\n
Plateformes\u00a0:<\/strong><\/h3>\n
Plateforme de Cytom\u00e9trie, analyse cellulaire et tri (CyACT)\u00a0: tharshana.stephen@cea.fr<\/a>
Plateforme de Cytog\u00e9n\u00e9tique (CytoG)\u00a0: christine.granotier@cea.fr<\/a>
Plateforme d\u2019exp\u00e9rimentation sur les mod\u00e8les pr\u00e9cliniques (EMP)\u00a0: vilma.barroca@cea.fr<\/a>
Plateforme d\u2019Irradiation X et gamma (IRX\u0263)\u00a0: veronique.menard@cea.fr<\/a>
Plateforme de microscopie photonique (MIP)\u00a0: lamya.irbah@cea.fr<\/a>
Plateforme d\u2019imagerie et de criblage cellulaire (PICCEL)\u00a0: guillaume.pinna@cea.fr<\/a>
Plateforme immunohistochimie multiplexe (PICH)\u00a0: sebastien.messiaen@cea.fr<\/a>
Zootechnie murine (ZooM)\u00a0: sylvia.vincent-naulleau@cea.fr<\/a><\/p>\nLocalisation\u00a0: <\/strong><\/h3>\n
CEA – DRF\/JACOB\/DRCM
B\u00e2timent 05
18 route du Panorama
92260 Fontenay-aux-Roses
France<\/p>\nSite interne\u00a0: <\/strong><\/h3>\n