{"id":1628,"date":"2021-01-09T09:32:54","date_gmt":"2021-01-09T08:32:54","guid":{"rendered":"https:\/\/u-paris.fr\/sdv\/?page_id=1628"},"modified":"2025-05-16T11:06:22","modified_gmt":"2025-05-16T09:06:22","slug":"structural-microbiology","status":"publish","type":"page","link":"https:\/\/u-paris.fr\/sdv\/structural-microbiology\/","title":{"rendered":"Structural Microbiology"},"content":{"rendered":"

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CCM<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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Tutelles\u00a0><\/div>\n
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Universit\u00e9 Paris Cit\u00e9<\/strong><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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UMR 3528<\/strong><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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The cell cycle is at the heart of all forms of life. Our main objective is to understand the mechanisms of the cell cycle in Mycobacteriales, a suborder of Actinobacteria that includes<\/span> Mycobacterium tuberculosis<\/b><\/i><\/span>, using<\/span> Corynebacterium glutamicum<\/b><\/i><\/span> <\/b>as a model organism.<\/span> We employ a mechanistic cell biology approach to study the division and elongation machineries and their spatiotemporal regulation. We are also interested in how the division machinery interacts with DNA remodeling systems to ensure efficient chromosome segregation. Our goal is to obtain direct structural insights into the global architecture of the divisome or its sub-complexes, using integrative structural biology methods.<\/span><\/p>\n

In parallel, we are developing<\/span> chemical and imaging tools for cell cycle research and antimicrobial discovery.<\/b><\/span> The cell wall is the target of several anti-tuberculosis antibiotics. We exploit cell morphologies resulting from growth defects to discover chemical compounds targeting essential cell cycle mechanisms. In parallel, we use <\/span>DNA gyrase as a validated target<\/b><\/span> to study relevant compounds against tuberculosis, both through structural characterization (cryo-EM of complexes) and phenotypic analysis using our model system\u00a0<\/span>C. glutamicum<\/i><\/span>.<\/span><\/p>\n

We are developing an innovative screening and characterization pipeline based on high-content imaging and AI-driven analysis, enabling the discovery of anti-mycobacterial drugs in a non-pathogenic model system, before testing the most promising compounds directly on\u00a0<\/span>M. tuberculosis<\/i><\/span>.<\/span><\/p>\n

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Equipes de recherche<\/h3>\n
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Responsable : Anne Marie WEHENKEL<\/strong><\/p>\n

Marie DE TARRAGON : Assistante administrative
Mariano MARTINEZ : Ing\u00e9nieur de recherche
St\u00e9phanie PETRELLA : Enseignante\/Chercheuse permanente – Universit\u00e9 Paris Cit\u00e9
Giacomo CARLONI : Etudiant en th\u00e8se
Ya\u00eblle WORMSER : Etudiante en th\u00e8se
Yves-Marie BOUDEHEN : Post-doc
Julienne PETIT : Post-doc<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Lien(s) web\u00a0><\/div>\n
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https:\/\/research.pasteur.fr\/fr\/team\/bacterial-cell-cycle-mechanisms\/<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Localisation<\/h3>\n
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INSTITUT PASTEUR<\/div>\n
25-28, rue du Docteur Roux
75015 PARIS
3e \u00e9tage Metchnikoff<\/strong><\/div>\n
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France<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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CCM \u00a0 Tutelles\u00a0> Universit\u00e9 Paris Cit\u00e9 \u00a0 UFR de rattachement\u00a0> Sciences du Vivant \u00a0\u00a0 Label unit\u00e9\u00a0> UMR 3528 \u00a0\u00a0 Pr\u00e9sentation The cell cycle is at the heart of all forms of life. Our main objective is to understand the mechanisms of the cell cycle in Mycobacteriales, a suborder of Actinobacteria that includes Mycobacterium tuberculosis, using… Lire la suite Structural Microbiology<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"coauthors":[17],"class_list":["post-1628","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/comments?post=1628"}],"version-history":[{"count":7,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1628\/revisions"}],"predecessor-version":[{"id":3591,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1628\/revisions\/3591"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/media?parent=1628"}],"wp:term":[{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/coauthors?post=1628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}