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Le cycle cellulaire est au c\u0153ur de toutes les formes de vie. Notre objectif principal est de comprendre les m\u00e9canismes du cycle cellulaire chez les Mycobacteriales, <\/span>un sous-ordre des Actinobacteries incluant<\/span> Mycobacterium tuberculosis <\/b><\/i><\/span>et<\/span> en utilisant <\/span>Corynebacterium glutamicum<\/i><\/span> comme organisme mod\u00e8le. Nous employons une approche de biologie cellulaire m\u00e9canistique pour \u00e9tudier les machineries de division et d’\u00e9longation, et leur r\u00e9gulation spatio-temporelle. <\/span>Nous nous int\u00e9ressons \u00e9galement \u00e0 la mani\u00e8re dont la machinerie de division interagit avec les syst\u00e8mes de remodelage de l\u2019ADN pour assurer une s\u00e9gr\u00e9gation chromosomique efficace.<\/span>Nous visons \u00e0 obtenir des informations structurales directes sur l’architecture globale du divisome ou de ses sous-complexes, en utilisant des <\/span>m\u00e9thodes int\u00e9gratives de biologie structurale<\/b><\/span>.<\/span><\/p>\n En parall\u00e8le, nous d\u00e9veloppons des <\/span>outils chimiques et d’imagerie pour la recherche sur le cycle cellulaire et la d\u00e9couverte d’antimicrobiens<\/b><\/span>. La paroi cellulaire est la cible de plusieurs antibiotiques anti-tuberculeux. Nous exploitons les morphologies cellulaires resultants de d\u00e9fauts de croissance pour d\u00e9couvrir des compos\u00e9s chimiques ciblant des m\u00e9canismes essentiels du cycle cellulaire. Nous utilisons en parallele <\/span>l’ADN gyrase comme cible valid\u00e9e<\/b><\/span> pour \u00e9tudier les compos\u00e9s pertinents contre la tuberculose, \u00e0 la fois par caract\u00e9risation structurale (cryo-EM de complexes) et par analyse ph\u00e9notypique en utilisant notre syst\u00e8me mod\u00e8le <\/span>C. glutamicum<\/i><\/span>.<\/span><\/p>\n \n Nous d\u00e9veloppons un pipeline innovant de criblage et de caract\u00e9risation bas\u00e9 sur l’imagerie \u00e0 haut contenu et l’analyse pilot\u00e9e par l’IA, permettant d’aborder la d\u00e9couverte de m\u00e9dicaments antimycobact\u00e9riens dans un syst\u00e8me mod\u00e8le non pathog\u00e8ne, avant de tester les mol\u00e9cules les plus prometteuses directement sur <\/span>M. tuberculosis<\/i><\/span>.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n Responsable : Anne Marie WEHENKEL<\/strong><\/p>\n Marie DE TARRAGON : Assistante administrative France<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb3.22″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2″ _builder_version=\u00a0\u00bb3.0.47″][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2″ _builder_version=\u00a0\u00bb3.0.47″][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" BCCM \u00a0 Tutelles\u00a0> Universit\u00e9 Paris Cit\u00e9 \u00a0 UFR de rattachement\u00a0> Sciences du Vivant \u00a0 Label unit\u00e9\u00a0> UMR 3528 \u00a0 Pr\u00e9sentation Le cycle cellulaire est au c\u0153ur de toutes les formes de vie. Notre objectif principal est de comprendre les m\u00e9canismes du cycle cellulaire chez les Mycobacteriales, un sous-ordre des Actinobacteries incluant Mycobacterium tuberculosis et en… Lire la suite M\u00e9canismes du Cycle Cellulaire Bact\u00e9rien<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"coauthors":[17],"class_list":["post-1631","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1631","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/comments?post=1631"}],"version-history":[{"count":36,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1631\/revisions"}],"predecessor-version":[{"id":3602,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/pages\/1631\/revisions\/3602"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/media?parent=1631"}],"wp:term":[{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sdv\/wp-json\/wp\/v2\/coauthors?post=1631"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Unit\u00e9 de recherche<\/h3>\n
Mariano MARTINEZ : Ing\u00e9nieur de recherche
St\u00e9phanie PETRELLA : Enseignante\/Chercheuse permanente – Universit\u00e9 Paris Cit\u00e9
Giacomo CARLONI : Etudiant en th\u00e8se
Ya\u00eblle WORMSER : Etudiante en th\u00e8se
Yves-Marie BOUDEHEN : Post-doc
Julienne PETIT : Post-doc<\/p>\n<\/div>\n<\/div>\n<\/div>\nLocalisation<\/h3>\n
75015 PARIS
3e \u00e9tage Metchnikoff<\/strong><\/div>\n