Autoimmunity/inflammation Through RNAseq Analysis at the single Cell level for Therapeutic Innovation – ATRACTion

Project Summary

Primary Immune Deficiencies (PIDs) comprise different monogenic diseases related to developmental or functional dysfunction of one or several immune cell types. Autoimmunity/inflammation in PIDs can arise from different causes and its onset and presentation is highly unpredictable. As classical approaches to cellular and molecular analysis have many limitations, we propose a transversal project that uses single-cell technologies combined with multi-OMICS analysis in a spectrum of genetically well-defined PIDs resulting in autoimmunity/inflammation. The interpretation of the massive and complex data collected will be assisted by machine learning-driven network inferences and, therefore, enable the identification of personalised disease signatures. Our goal is to develop ground-breaking and transformative diagnostic and prognostic tools and to define personalised therapeutic approaches for pediatric patients suffering from autoimmunity/inflammation linked to PIDs.

Mickaël Ménager