Genetic Stability, Stem Cells and Radiation

Version française

Acronym: SGCSR
Supervising Institutions: Université Paris Cité, Université Paris-Saclay, Inserm, CEA
Affiliated Faculty: Life Sciences
Research Unit Identifier: UMRE008-U1274

Director: Stéphane MARCAND (stephane.marcand@cea.fr)
Deputy Director: Françoise PFLUMIO (francoise.pflumio@cea.fr)
Administrative Manager: Aurélie GOURET (secretariat-u1274@cea.fr)

Overview :

The Joint Research Unit Genetic Stability, Stem Cells and Radiation (SGCSR) focuses its research on the molecular mechanisms responsible for DNA damage repair and genome stability, as well as on normal and cancer stem cells (germline, hematopoietic, epidermal and neural).

By combining these two research areas, the unit’s teams are able to conduct innovative research into cellular and tissue responses to genotoxic stress, particularly stress associated with exposure to ionizing radiation.

To this end, they use a range of model systems (Saccharomyces cerevisiae, Helicobacter pylori), 2D and 3D cultures of primary cells and cell lines (human or mouse), as well as preclinical models (mice).

The overall objective is to improve our understanding of the development of various cancerous and non-cancerous diseases, with a view to proposing new, targeted preventive and/or therapeutic strategies.

Publication List :

https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/Departments/IRCM/Productions.aspx

Research Teams :

Platforms and Core Facilities :

Location :

UMR SGCSR
CEA – DRF/JACOB/DRCM
Building 05
18 route du Panorama
92260 Fontenay-aux-Roses
France

Website

https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/Departments/IRCM.aspx