3 ème journée scientifique de l’IHM Maladies OstéoArticulaires

L’Institut Hors-Murs des Maladies OstéoArticulaires (IHM MOA), a pour a pour objectif de fédérer la recherche sur ce thème au sein d’Université de Paris Cité.

Nous vous invitons à la 3 ème journée scientifique de l’IHM MOA qui aura lieu
Jeudi 9 mars 2023 de 14h à 18h
Amphithéâtre Portier
Université Paris-Cité, 15 rue de l’Ecole de Médecine, 75006 Paris

Notre invité d’honneur sera :

• Pr. Léo Joosten, Radboud University Medical Centre, Nijmegen, The Netherlands : Trained immunity, memory of innate immunity in health and diseases

Prof. Leo A.B. Joosten is a pathobiologist and full professor of mechanisms of inflammatory diseases at Radboud University in Nijmegen, The Netherlands. He is a leading international scientist in the areas of inflammation and infectious diseases. Joosten worked for more than 25 years in Rheumatology research identifying mechanisms of cartilage and bone destruction. One of his discoveries was that IL-1 is the pivotal cytokine mediating joint destruction. His research during the past ten years has focused on the role of cytokines in the pathogenesis of chronic inflammation and was aimed to find novel inhibitors to treat patients with these inflammatory diseases. His group has covered the contribution of PRR (TLR and NLR) in the chronicity of inflammation. They discovered multiple novel inflammatory cytokines and mechanisms of cell regulation of inflammasome activation. Very recently, they explore the intra- and inter-individual variability of the human immune system, focus on environmental factors, genetics, microbiome.
Especially, they explored the role of immunometabolism and epigenetic reprogramming in the induction of innate immune memory or trained immunity. Joosten has published more than 600 scientific publications, in the top scientific and medical journals, including papers in Science, New England Journal of Medicine, Cell, Nature Medicine, PNAS. His H-index is 114 and his work is cited
more than 52.549 times. A recent (2020 and 2021) search for the world most cited researchers (Clarivate Analytics, Highly Cited Researchers) showed that Joosten belongs to the top 1% (CrossField and Immunology). Joosten is owner of 8 international patents in the field of diagnostics and
therapeutics.

From Joosten’s Lab

• The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Rep. 2021;35(1):10895Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.
  Ann Rheum Dis. 2020;79:536-544.
• Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway. Proc Natl Acad Sci U S A.
  2017;114:5485-5490.
• A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans. Cell. 2016;167:1099-
  1110.
• Host and Environmental Factors Influencing Individual Human Cytokine Responses. Cell. 2016;167:1111-1124.

INSCRIPTION

PROGRAMME

Evénement réservé aux chercheuses et chercheurs d’Université Paris Cité travaillant sur la thématique.