Publications

Who Am I? funding has supported the publication of more than 370 articles and monographs, including 44 in 2021. A third of these publications include, as their first author, young researchers funded by the Labex.

Publications 2021

Amyloid Beta Peptide Is an Endogenous Negative Allosteric Modulator of Leptin Receptor. Cecon E, Lhomme T, Maurice T, Luka M, Chen M, Silva A, Wauman J, Zabeau L, Tavernier J, Prévot V, Dam J, Jockers R. Neuroendocrinology. 2021;111(4):370-387. doi: 10.1159/000508105. Epub 2020 Apr 24.

Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5-HT2C receptor heteromers in mouse brain. Gerbier R, Ndiaye-Lobry D, Martinez de Morentin PB, Cecon E, Heisler LK, Delagrange P, Gbahou F, Jockers R. FASEB J. 2021 Jan;35(1):e21161. doi: 10.1096/fj.202000305R. Epub 2020 Nov 6.

Get Out and Stay Out: New Insights Into DNA Methylation Reprogramming in Mammals. Greenberg MVC. Front Cell Dev Biol. 2021 Jan 7;8:629068. doi: 10.3389/fcell.2020.629068. ECollection 2020

Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion. Le AP, Rupprecht JF, Mège RM, Toyama Y, Lim CT, Ladoux B. Nat Commun. 2021 Jan 15;12(1):397. doi: 10.1038/s41467-020-20563-9.

FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability. Fernandes P, Miotto B, Saint-Ruf C, Said M, Barra V, Nähse V, Ravera S, Cappelli E, Naim V. Commun Biol. 2021 Jan 29;4(1):127. doi: 10.1038/s42003-021-01647-8.

Animal regeneration in the era of transcriptomics. Bideau L, Kerner P, Hui J, Vervoort M, Gazave E. Cell Mol Life Sci. 2021 Jan 30. doi: 10.1007/s00018-021-03760-7. Online ahead of print.

Male genital lobe morphology affects the chance to copulate in Drosophila pachea. Lefèvre BM, Catté D, Courtier-Orgogozo V, Lang M. BMC Ecol Evol. 2021 Feb 11;21(1):23. doi: 10.1186/s12862-021-01759-z.

Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège RM, Yeomans JM, Ladoux B. Nat Mater. 2021 Feb 18. doi: 10.1038/s41563-021-00919-2. Online ahead of print.

Role of heat shock transcription factor 2 in the NMDA-dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. Drissi I, Deschamps C, Alary R, Robert A, Dubreuil V, Le Mouël A, Mohammed M, Sabéran-Djoneidi D, Mezger V, Naassila M, Pierrefiche O. Addict Biol. 2021 Mar;26(2):e12939. doi: 10.1111/adb.12939. Epub 2020 Jul 27.

The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis. Blondel-Tepaz E, Leverve M, Sokrat B, Paradis JS, Kosic M, Saha K, Auffray C, Lima-Fernandes E, Zamborlini A, Poupon A, Gaboury L, Findlay J, Baillie GS, Enslen H, Bouvier M, Angers S, Marullo S, Scott MGH. Oncogene. 2021 Mar;40(12):2243-2257. doi: 10.1038/s41388-021-01704-w. Epub 2021 Mar 1.

Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy. Chen J, Nelson C, Wong M, Tee AE, Liu PY, La T, Fletcher JI, Kamili A, Mayoh C, Bartenhagen C, Trahair TN, Xu N, Jayatilleke N, Wong M, Peng H, Atmadibrata B, Cheung BB, Lan Q, Bryan TM, Mestdagh P, Vandesompele J, Combaret V, Boeva V, Wang JY, Janoueix-Lerosey I, Cowley MJ, MacKenzie KL, Dolnikov A, Li J, Polly P, Marshall GM, Reddel RR, Norris MD, Haber M, Fischer M, Zhang XD, Pickett HA, Liu T. Clin Cancer Res. 2021 Mar 1;27(5):1438-1451. doi: 10.1158/1078-0432.CCR-20-3044. Epub 2020 Dec 11.

Three-dimensional architecture of nephrons in the normal and cystic kidney. Blanc T, Goudin N, Zaidan M, Traore MG, Bienaime F, Turinsky L, Garbay S, Nguyen C, Burtin M, Friedlander G, Terzi F, Pontoglio M. Kidney Int. 2021 Mar;99(3):632-645. doi: 10.1016/j.kint.2020.09.032. Epub 2020 Oct 31.

Data from crosslinking and analysis of cDNAs (CRAC) of Nab3 in yeast cells expressing a circular ncRNA decoy. Villa T, Jaszczyszyn Y, Libri D. Data Brief. 2021 Mar 15;35:106951. doi: 10.1016/j.dib.2021.106951. eCollection 2021 Apr.

* Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry. Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G, Joly N, Poteau M, Velez-Aguilera G, Gavet O, Castro A, Dasso M, Lorca T, Sicheri F, Pintard L. Nat Commun. 2021 Mar 26;12(1):1899. doi: 10.1038/s41467-021-21922-w.

Chromatin Immunoprecipitation Followed by Next-Generation Sequencing (ChIP-Seq) Analysis in Ewing Sarcoma. Kerdivel G, Boeva V. Methods Mol Biol. 2021;2226:265-284. doi: 10.1007/978-1-0716-1020-6_21.

Introducing secretory reticulophagy/ER-phagy (SERP), a VAMP7-dependent pathway involved in neurite growth. Vats S, Galli T. Autophagy. 2021 Apr;17(4):1037-1039. doi: 10.1080/15548627.2021.1883886. Epub 2021 Feb 8.

Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry. Watzky M, de Dieuleveult M, Letessier A, Saint-Ruf C, Miotto B. Environ Res. 2021 Apr;195:110317. doi: 10.1016/j.envres.2020.110317. Epub 2020 Oct 15.

* Staying true to yourself: mechanisms of DNA methylation maintenance in mammals. Petryk N, Bultmann S, Bartke T, Defossez PA. Nucleic Acids Res. 2021 Apr 6;49(6):3020-3032. doi: 10.1093/nar/gkaa1154.

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization. Gaston C, De Beco S, Doss B, Pan M, Gauquelin E, D’Alessandro J, Lim CT, Ladoux B, Delacour D. Nat Commun. 2021 Apr 13;12(1):2226. doi: 10.1038/s41467-021-22482-9.

Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance. Fortuny A, Chansard A, Caron P, Chevallier O, Leroy O, Renaud O, Polo SE. Nat Commun. 2021 Apr 23;12(1):2428. doi: 10.1038/s41467-021-22575-5.

Transient cell stiffening triggered by magnetic nanoparticle exposure. Perez JE, Fage F, Pereira D, Abou-Hassan A, Asnacios S, Asnacios A, Wilhelm C. J Nanobiotechnology. 2021 Apr 26;19(1):117. doi: 10.1186/s12951-021-00790-y.

[A trio of mechanisms involved in regeneration initiation in animals]. Vullien A, Röttinger É, Vervoort M, Gazave E. Med Sci (Paris). 2021 Apr;37(4):349-358. doi: 10.1051/medsci/2021037. Epub 2021 Apr 28

*Control of the chromatin response to DNA damage: Histone proteins pull the strings. Ferrand J, Plessier A, Polo SE. Semin Cell Dev Biol. 2021 May;113:75-87. doi: 10.1016/j.semcdb.2020.07.002. Epub 2020 Jul 18.

* The chromatin remodelling protein LSH/HELLS regulates the amount and distribution of DNA hydroxymethylation in the genome. De Dieuleveult M, Bizet M, Colin L, Calonne E, Bachman M, Li C, Stancheva I, Miotto B, Fuks F, Deplus R. Epigenetics. 2021 May 7:1-22. doi: 10.1080/15592294.2021.1917152. Online ahead of print.

* Integrity of the short arm of the nuclear pore Y-complex is required for mouse embryonic stem cell growth and differentiation. Gonzalez-Estevez A, Verrico A, Orniacki C, Reina-San-Martin B, Doye V. J Cell Sci. 2021 May 15;134(10):jcs258340. doi: 10.1242/jcs.258340. Epub 2021 May 26.

*$ A morphological trait involved in reproductive isolation between Drosophila sister species is sensitive to temperature. Peluffo AE, Hamdani M, Vargas-Valderrama A, David JR, Mallard F, Graner F, Courtier-Orgogozo V. Ecol Evol. 2021 May 25;11(12):7492-7506. doi: 10.1002/ece3.7580. eCollection 2021 Jun.

*$ Dynamic methylation of histone H3K18 in differentiating Theileria parasites. Cheeseman K, Jannot G, Lourenço N, Villares M, Berthelet J, Calegari-Silva T, Hamroune J, Letourneur F, Rodrigues-Lima F, Weitzman JB. Nat Commun. 2021 May 28;12(1):3221. doi: 10.1038/s41467-021-23477-2.

* Light and shadow on the mechanisms of integration site selection in yeast Ty retrotransposon families. Bonnet A, Lesage P. Curr Genet. 2021 Jun;67(3):347-357. doi: 10.1007/s00294-021-01154-7. Epub 2021 Feb 15.

Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA. Bouvier D, Ferrand J, Chevallier O, Paulsen MT, Ljungman M, Polo SE. Nat Commun. 2021 Jun 22;12(1):3835. doi: 10.1038/s41467-021-24153-1.

* Cell migration guided by long-lived spatial memory. d’Alessandro J, Barbier-Chebbah A, Cellerin V, Benichou O, Mège RM, Voituriez R, Ladoux B. Nat Commun. 2021 Jul 5;12(1):4118. doi: 10.1038/s41467-021-24249-8.

Massive colonization of protein-coding exons by selfish genetic elements in Paramecium germline genomes. Sellis D, Guérin F, Arnaiz O, Pett W, Lerat E, Boggetto N, Krenek S, Berendonk T, Couloux A, Aury JM, Labadie K, Malinsky S, Bhullar S, Meyer E, Sperling L, Duret L, Duharcourt S. PLoS Biol. 2021 Jul 29;19(7):e3001309. doi: 10.1371/journal.pbio.3001309. eCollection 2021 Jul.

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function. Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Prévot V. Nat Metab. 2021 Aug;3(8):1071-1090. doi: 10.1038/s42255-021-00432-5. Epub 2021 Aug 2.

Multiscale rheology of glioma cells. Alibert C, Pereira D, Lardier N, Etienne-Manneville S, Goud B, Asnacios A, Manneville JB. Biomaterials. 2021 Aug;275:120903. doi: 10.1016/j.biomaterials.2021.120903. Epub 2021 May 26.

$ DNA methylation atlas and machinery in the developing and regenerating annelid Platynereis dumerilii. Planques A, Kerner P, Ferry L, Grunau C, Gazave E, Vervoort M. BMC Biol. 2021 Aug 3;19(1):148. doi: 10.1186/s12915-021-01074-5.

* 3D Shape of Epithelial Cells on Curved Substrates. Harmand N, Huang A, Hénon S. Phys. Rev. X. 11, 031028 – Published 4 August 2021. doi: 10.1103/PhysRevX.11.031028.

* Genome-wide and sister chromatid-resolved profiling of protein occupancy in replicated chromatin with ChOR-seq and SCAR-seq. Petryk N, Reverón-Gómez N, González-Aguilera C, Dalby M, Andersson R, Groth A. Nat Protoc. 2021 Aug 6. doi: 10.1038/s41596-021-00585-3. Online ahead of print.

CHIPIN: ChIP-seq inter-sample normalization based on signal invariance across transcriptionally constant genes. Polit L, Kerdivel G, Gregoricchio S, Esposito M, Guillouf C, Boeva V. BMC Bioinformatics. 2021 Aug 17;22(1):407. doi: 10.1186/s12859-021-04320-3.

DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks. Caron P, Pobega E, Polo SE. Front Genet. 2021 Sep 1;12:730696. doi: 10.3389/fgene.2021.730696. eCollection 2021.

The Nereid on the rise: Platynereis as a model system. Özpolat BD, Randel N, Williams EA, Bezares-Calderón LA, Andreatta G, Balavoine G, Bertucci PY, Ferrier DEK, Gambi MC, Gazave E, Handberg-Thorsager M, Hardege J, Hird C, Hsieh YW, Hui J, Mutemi KN, Schneider SQ, Simakov O, Vergara HM, Vervoort M, Jékely G, Tessmar-Raible K, Raible F, Arendt D. Evodevo. 2021 Sep 27;12(1):10. doi: 10.1186/s13227-021-00180-3.

Mechanical plasticity in collective cell migration. Jain S, Ladoux B, Mège RM. Curr Opin Cell Biol. 2021 Oct;72:54-62. doi: 10.1016/j.ceb.2021.04.006. Epub 2021 Jun 13.

Role of Polycomb in the control of transposable elements. Déléris A, Berger F, Duharcourt S. Trends Genet. 2021 Oct;37(10):882-889. doi: 10.1016/j.tig.2021.06.003. Epub 2021 Jun 28.

* Real-time tracking of root hair nucleus morphodynamics using a microfluidic approach. Singh G, Pereira D, Baudrey S, Hoffmann E, Ryckelynck M, Asnacios A, Chabouté ME. Plant J. 2021 Oct;108(2):303-313. doi: 10.1111/tpj.15511. Epub 2021 Oct 10.

§ Direct measurement of near-nano-Newton forces developed by self-organizing actomyosin fibers bound α-catenin. Sonam S, Vigouroux C, Jégou A, Romet-Lemonne G, Le Clainche C, Ladoux B, Mège RM. Biol Cell. 2021 Nov;113(11):441-449. doi: 10.1111/boc.202100014. Epub 2021 Aug 20.

*§ A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription. Bonnet A, Chaput C, Palmic N, Palancade B, Lesage P. PLoS Genet. 2021 Nov 1;17(11):e1009889. doi: 10.1371/journal.pgen.1009889. eCollection 2021 Nov.

* Bioengineering methods for organoid systems. Saleh J, Mercier B, Xi W. Biol Cell. 2021 Dec;113(12):475-491. doi: 10.1111/boc.202000119. Epub 2021 Oct 13.

Glue Genes Are Subjected to Diverse Selective Forces during Drosophila Development. Borne F, Kulathinal RJ, Courtier-Orgogozo V. Genome Biol Evol. 2021 Dec 1;13(12):evab248. doi: 10.1093/gbe/evab248.

Control of the Mdm2-p53 signal loop by β-arrestin 2: The ins and outs. Blondel-Tepaz E, Enslen H, Scott MGH. Oncotarget. 2021 Dec 21;12(26):2543-2545. doi: 10.18632/oncotarget.28065. eCollection 2021 Dec 21.

* The Annelid Platynereis dumerilii as an Experimental Model for Evo-Devo and Regeneration Studies. Schenkelaars Q, Gazave, E. CRC Press. Book chapter. 2021; p23. Handbook of Marine Model Organisms in Experimental Biology: Established and Emerging (1st ed.). doi: 10.1201/9781003217503.

Que serait « ma » douleur sans l’autre ? Les saisissements de la douleur. Places, dimensions et mouvements. Villa F. Corps & psychisme. Recherches en psychanalyse et sciences humaines, 2021, nº 78, p. 79-89.

* First author received Labex funding (PhD, post-doc or transition post-doc)
§ article co-signed by at least 2 Labex partners

Publications 2020

X chromosome inactivation in human development. Patrat C, Ouimette JF, Rougeulle C. Development. 2020 Jan 3;147(1):dev183095. doi: 10.1242/dev.183095.

* β-Arrestin-2 BRET Biosensors Detect Different β-Arrestin-2 Conformations in Interaction with GPCRs. Oishi A, Dam J, Jockers R. ACS Sens. 2020 Jan 24;5(1):57-64. doi: 10.1021/acssensors.9b01414. Epub 2019 Dec 31.

Reading DNA Modifications. Baubec T, Defossez PA. J Mol Biol. 2020 Feb 8:S0022-2836(20)30096-6. doi: 10.1016/j.jmb.2020.02.001. Online ahead of print.

Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability. Appanah R, Lones EC, Aiello U, Libri D, De Piccoli G. Cell Rep. 2020 Feb 18;30(7):2094-2105.e9. doi: 10.1016/j.celrep.2020.01.087.

A subtle relationship between substrate stiffness and collective migration of cell clusters. Balcioglu HE, Balasubramaniam L, Stirbat TV, Doss BL, Fardin MA, Mège RM, Ladoux B. Soft Matter. 2020 Feb 21;16(7):1825-1839. doi: 10.1039/c9sm01893j. Epub 2020 Jan 23.

Desmosomal Junctions Govern Tissue Integrity and Actomyosin Contractility in Apoptotic Cell Extrusion. Thomas M, Ladoux B, Toyama Y. Curr Biol. 2020 Feb 24;30(4):682-690.e5. doi: 10.1016/j.cub.2020.01.002. Epub 2020 Jan 30.

* Ubiquitin Dynamics in Stem Cell Biology: Current Challenges and Perspectives. de Dieuleveult M, Miotto B. Bioessays. 2020 Mar;42(3):e1900129. doi: 10.1002/bies.201900129. Epub 2020 Jan 22.

Intracellular Theileria Parasites PIN Down Host Metabolism. Medjkane S, Weitzman JB. Front Cell Dev Biol. 2020 Mar 17;8:134. doi: 10.3389/fcell.2020.00134. ECollection 2020.

* Termination of non-coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD-mimicking region in Sen1. Han Z, Jasnovidova O, Haidara N, Tudek A, Kubicek K, Libri D, Stefl R, Porrua O. EMBO J. 2020 Apr 1;39(7):e101548. doi: 10.15252/embj.2019101548. Epub 2020 Feb 28.

Designer substrates and devices for mechanobiology study. Xi W, Delacour D, and Ladoux B. Journal of Semiconductors (2020) 41, 041607. doi: 10.1088/1674-4926/41/4/041607.

The clever strategies used by intracellular parasites to hijack host gene expression. Villares M, Berthelet J, Weitzman JB. Semin Immunopathol. 2020 Apr;42(2):215-226. doi: 10.1007/s00281-020-00779-z. Epub 2020 Jan 30.

Editorial: Gene Regulation From the X-Chromosome During Development and Disease. Anguera MC, Payer B, Morey C. Front Cell Dev Biol. 2020 Apr 23;8:272. doi: 10.3389/fcell.2020.00272. ECollection 2020.

* Molecular and Clinical Relevance of ZBTB38 Expression Levels in Prostate Cancer. de Dieuleveult M, Marchal C, Jouinot A, Letessier A, Miotto B. Cancers (Basel). 2020 Apr 29;12(5):1106. doi: 10.3390/cancers12051106.

Acute conversion of patient-derived Duchenne Muscular Dystrophy iPSC into myotubes, reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling. Caputo L, Granados A, Lenzi J, Rosa A, Ait-Si-Ali S, Puri PL & Albini S. Skelet Muscle. 2020 May 2;10(1):13. doi: 10.1186/s13395-020-00224-7.

Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins. Chen M, Cecon E, Karamitri A, Gao W, Gerbier R, Ahmad R, Jockers R. J Pineal Res. 2020 May;68(4):e12641. doi: 10.1111/jpi.12641. Epub 2020 Mar 6.

Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P. Cell Death Dis. 2020 May 12;11(5):360. doi: 10.1038/s41419-020-2556-3.

The Impact of Neutral Mutations on Genome Evolvability. Tenaillon O, Matic I. Curr Biol. 2020 May 18;30(10):R527-R534. doi: 10.1016/j.cub.2020.03.056.

* Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity. Trentesaux C, Fraudeau M, Pitasi CL, Lemarchand J, Jacques S, Duche A, Letourneur F, Naser E, Bailly K, Schmitt A, Perret C, Romagnolo B. Proc Natl Acad Sci U S A. 2020 May 19;117(20):11136-11146. doi: 10.1073/pnas.1917174117. Epub 2020 May 5.

Structure-Based Virtual Screening Accelerates GPCR Drug Discovery. Liu L, Jockers R. Trends Pharmacol Sci. 2020 Jun;41(6):382-384. doi: 10.1016/j.tips.2020.04.001. Epub 2020 Apr 24.

Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development. Joly N, Beaumale E, Van Hove L, Martino L, Pintard L. J Cell Biol. 2020 Jun 1;219(6):e201912037. doi: 10.1083/jcb.201912037.

Mechanical Shielding in Plant Nuclei. Goswami R, Asnacios A, Milani P, Graindorge S, Houlné G, Mutterer J, Hamant O, Chabouté ME. Curr Biol. 2020 Jun 8;30(11):2013-2025.e3. doi: 10.1016/j.cub.2020.03.059. Epub 2020 Apr 23.

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress. Doss BL, Pan M, Gupta M, Grenci G, Mège RM, Lim CT, Sheetz MP, Voituriez R, Ladoux B. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12817-12825. doi: 10.1073/pnas.1917555117. Epub 2020 May 22.

The role of single cell mechanical behavior and polarity in driving collective cell migration. Jain S, Cachoux VML, Narayana GHNS, de Beco S, D’Alessandro J, Cellerin V, Chen T, Heuzé ML, Marcq P, Mège RM, Kabla AJ, Lim CT, Ladoux B. Nat Phys. 2020 Jul;16(7):802-809. doi: 10.1038/s41567-020-0875-z. Epub 2020 May 4.

Posttranslational Regulation and Conformational Plasticity of PTEN. Kotelevets L, Trifault B, Chastre E, Scott MGH. Cold Spring Harb Perspect Med. 2020 Jul 1;10(7):a036095. doi: 10.1101/cshperspect.a036095.

* Observing Nutrient Gradients, Gene Expression and Growth Variation Using the « Yeast Machine » Microfluidic Device. Marinkovic ZS, Vulin C, Acman M, Song X, Di Meglio JM, Lindner AB, Hersen P. Bio Protoc. 2020 Jul 5;10(13):e3668. doi: 10.21769/BioProtoc.3668. eCollection 2020 Jul 5.

Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells. Teo JL, Gomez GA, Weeratunga S, Davies EM, Noordstra I, Budnar S, Katsuno-Kambe H, McGrath MJ, Verma S, Tomatis V, Acharya BR, Balasubramaniam L, Templin RM, McMahon KA, Lee YS, Ju RJ, Stebhens SJ, Ladoux B, Mitchell CA, Collins BM, Parton RG, Yap AS. Dev Cell. 2020 Jul 6;54(1):75-91.e7. doi: 10.1016/j.devcel.2020.05.002. Epub 2020 Jun 1.

Control of the chromatin response to DNA damage: Histone proteins pull the strings. Ferrand J, Plessier A, Polo SE. Semin Cell Dev Biol. 2020 Jul 18:S1084-9521(19)30096-5. doi: 10.1016/j.semcdb.2020.07.002. Online ahead of print.

Degradation of Non-coding RNAs Promotes Recycling of Termination Factors at Sites of Transcription. Villa T, Barucco M, Martin-Niclos MJ, Jacquier A, Libri D. Cell Rep. 2020 Jul 21;32(3):107942. doi: 10.1016/j.celrep.2020.107942.

The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements. de Vanssay A, Touzeau A, Arnaiz O, Frapporti A, Phipps J, Duharcourt S. PLoS Genet. 2020 Jul 23;16(7):e1008949. doi: 10.1371/journal.pgen.1008949. eCollection 2020 Jul.

Human Microphysiological Models of Intestinal Tissue and Gut Microbiome. Steinway SN, Saleh J, Koo BK, Delacour D, Kim DH. Front Bioeng Biotechnol. 2020 Jul 31;8:725. doi: 10.3389/fbioe.2020.00725. ECollection 2020.

* Ratiometric quorum sensing governs the trade-off between bacterial vertical and horizontal antibiotic resistance propagation. Banderas A, Carcano A, Sia E, Li S, Lindner AB. PLoS Biol. 2020 Aug 14;18(8):e3000814. doi: 10.1371/journal.pbio.3000814. eCollection 2020 Aug.

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing. Bruhn C, Ajazi A, Ferrari E, Lanz MC, Batrin R, Choudhary R, Walvekar A, Laxman S, Longhese MP, Fabre E, Smolka MB, Foiani M. Nat Commun. 2020 Aug 19;11(1):4154. doi: 10.1038/s41467-020-17961-4.

A small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes. Asif-Laidin A, Conesa C, Bonnet A, Grison C, Adhya I, Menouni R, Fayol H, Palmic N, Acker J, Lesage P. EMBO J. 2020 Sep 1;39(17):e104337. doi: 10.15252/embj.2019104337. Epub 2020 Jul 17.

Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function. Menant A, Karess RE. Biol Cell. 2020 Oct;112(10):300-315. doi: 10.1111/boc.201900105. Epub 2020 Jul 20.

* PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly. Velez-Aguilera G, Nkombo Nkoula S, Ossareh-Nazari B, Link J, Paouneskou D, Van Hove L, Joly N, Tavernier N, Verbavatz JM, Jantsch V, Pintard L. Elife. 2020 Oct 8;9:e59510. doi: 10.7554/eLife.59510.

Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry. Watzky M, de Dieuleveult M, Letessier A, Saint-Ruf C, Miotto B. Environ Res. 2020 Oct 15:110317. doi: 10.1016/j.envres.2020.110317. Online ahead of print.

Is the plant nucleus a mechanical rheostat? Goswami R, Asnacios A, Hamant O, Chabouté ME. Curr Opin Plant Biol. 2020 Oct;57:155-163. doi: 10.1016/j.pbi.2020.09.001. Epub 2020 Oct 29.

Histone Variants: Guardians of Genome Integrity. Ferrand J, Rondinelli B, Polo SE. Cells. 2020 Nov 5;9(11):2424. doi: 10.3390/cells9112424.

*§ Cell geometry and the cytoskeleton impact the nucleo-cytoplasmic localisation of the SMYD3 methyltransferase. Pereira D, Richert A, Medjkane S, Hénon S, Weitzman JB. Sci Rep. 2020 Nov 26;10(1):20598. doi: 10.1038/s41598-020-75833-9.

*§ GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors. Ahmad R, Lahuna O, Sidibe A, Daulat A, Zhang Q, Luka M, Guillaume JL, Gallet S, Guillonneau F, Hamroune J, Polo S, Prévot V, Delagrange P, Dam J, Jockers R. Cell Mol Life Sci. 2020 Dec;77(24):5189-5205. doi: 10.1007/s00018-019-03440-7. Epub 2020 Jan 3.

*§ Beta-arrestins operate an on/off control switch for focal adhesion kinase activity. Alexander RA, Lot I, Saha K, Abadie G, Lambert M, Decosta E, Kobayashi H, Beautrait A, Borrull A, Asnacios A, Bouvier M, Scott MGH, Marullo S, Enslen H. Cell Mol Life Sci. 2020 Dec;77(24):5259-5279. doi: 10.1007/s00018-020-03471-5. Epub 2020 Feb 10.

* Staying true to yourself: mechanisms of DNA methylation maintenance in mammals. Petryk N, Bultmann S, Bartke T, Defossez PA. Nucleic Acids Res. 2020 Dec 9:gkaa1154. doi: 10.1093/nar/gkaa1154. Online ahead of print.

* Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents. Moretti C, Blanco M, Ialy-Radio C, Serrentino ME, Gobé C, Friedman R, Battail C, Leduc M, Ward MA, Vaiman D, Tores F, Cocquet J. Mol Biol Evol. 2020 Dec 16;37(12):3453-3468. doi: 10.1093/molbev/msaa175.

* Globins in the marine annelid Platynereis dumerilii shed new light on hemoglobin evolution in bilaterians. Song S, Starunov V, Bailly X, Ruta C, Kerner P, Cornelissen AJM, Balavoine G. BMC Evol Biol. 2020 Dec 29;20(1):165. doi: 10.1186/s12862-020-01714-4.

Maladie grave chez l’enfant et confrontation à la question de la mort : l’exemple du cancer pédiatrique. Araneda M. Dans Dialogue. 2020, 230(4). p. 159-177.

TSPT, psychanalyse et neurosciences. Bonard F., Dayan J., Villa F. Dans Études sur la mort. 2020/2 n° 154, p. 21-37.

Le travail de culture, une voie pour sortir du funeste laboratoire du totalitarisme ?Villa, F. Dans Psychanalyse et culture de Nathalie Zaltzman. Colloque de Cerisy, sous la direction de Jean-François Chiantaretto et Georges Gaillard. 2020, Paris, Ithaque.

Épigénétique, ADN et dynamique de la chromatine : où est la chance et où est la nécessité ? Sitbon D, Weitzman JB. Dans Le Hasard, le Calcul et la vie. Eds Gaudin, T., Maurel, M.C., Pomerol , J.C. Ed. ISTE Editions, Londres, 2020

L’émergence de la forme dans l’histoire de l’épigénétique. Weitzman JB. Dans L’explosion des formes de vie – êtres vivants et morphologie. Eds G Chapouthier and MC Maurel.   ISTE Publishing-Wiley, London, 2020.

Recherche et perspectives actuelles en biologie et en médecine. Weitzman J. Dans Dépasser l’humain ? AES-France. Les éditions du bien commun, 2020.

L’identité. Dictionnaire encyclopédique. Sous la dir. de J. Gayon, V. Courtier, A. Nicoglou, G. Pontarotti, F. Villa, J. Weitzman. Paris Folios Essais, Gallimard, 2020.

Publications 2019

Cell shape and substrate stiffness drive actin-based cell polarity. Gupta M, Doss BL, Kocgozlu L, Pan M, Mège RM, Callan-Jones A, Voituriez R, Ladoux B. Phys Rev E. 2019 Jan;99(1-1):012412. doi: 10.1103/PhysRevE.99.012412.

Morphological, cellular and molecular characterization of posterior regeneration in the marine annelid Platynereis dumerilii. Planques A, Malem J, Parapar J, Vervoort M, Gazave E. Dev Biol. 2019 Jan 15;445(2):189-210. doi: 10.1016/j.ydbio.2018.11.004. Epub 2018 Nov 13.

Mitotic Cell Division in Caenorhabditis elegans. Pintard L, Bowerman B. Genetics. 2019 Jan;211(1):35-73. doi: 10.1534/genetics.118.301367. Review.

Tissue mechanics at the interface between cell biology and materials science. Xi W, Saw TB, Delacour D, Lim CT, Ladoux B. Nature Reviews Materials 2019, 4, 23-44.

Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish. Cianciolo Cosentino C, Berto A, Pelletier S, Hari M, Loffing J, Neuhauss SCF, Doye V. Sci Rep. 2019 Mar 18;9(1):4750. doi: 10.1038/s41598-019-41202-4.

* The nature and intensity of mechanical stimulation drive different dynamics of MRTF-A nuclear redistribution after actin remodeling in myoblasts. Montel L, Sotiropoulos A, Hénon S. PLoS One. 2019 Mar 28;14(3):e0214385. doi: 10.1371/journal.pone.0214385. eCollection 2019.

A novel leptin receptor antagonist uncouples leptin’s metabolic and immune functions. Zabeau L, Wauman J, Dam J, Van Lint S, Burg E, De Geest J, Rogge E, Silva A, Jockers R, Tavernier J. Cell Mol Life Sci. 2019 Mar;76(6):1201-1214. doi: 10.1007/s00018-019-03004-9. Epub 2019 Jan 18.

Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain. Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P, Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R. J Pineal Res. 2019 Mar;66(2):e12540. doi: 10.1111/jpi.12540. Epub 2019 Jan 17

Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Kori S, Ferry L, Matano S, Jimenji T, Kodera N, Tsusaka T, Matsumura R, Oda T, Sato M, Dohmae N, Ando T, Shinkai Y, Defossez PA, Arita K. Structure. 2019 Mar 5;27(3):485-496.e7. doi: 10.1016/j.str.2018.11.012.

SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses. Folz H, Niño CA, Taranum S, Caesar S, Latta L, Waharte F, Salamero J, Schlenstedt G, Dargemont C. J Cell Sci. 2019 Apr 3;132(7). pii: jcs224279. doi: 10.1242/jcs.224279. PMID: 30837289

Single-molecule characterization of extrinsic transcription termination by Sen1 helicase. Wang S, Han Z, Libri D, Porrua O, Strick TR. Nat Commun. 2019 Apr 4;10(1):1545. doi: 10.1038/s41467-019-09560-9.

Large-scale curvature sensing by directional actin flow drives cellular migration mode switching. Chen T, Callan-Jones A, Fedorov E, Ravasio A, Brugués A, Ong HT, Toyama Y, Low BC, Trepat X, Shemesh T, Voituriez R, Ladoux B. Nat Phys. 2019 Apr;15:393-402. doi: 10.1038/s41567-018-0383-6. Epub 2019 Jan 21.

Influence of proliferation on the motions of epithelial monolayers invading adherent strips. Gauquelin E, Tlili S, Gay C, Peyret G, Mège RM, Fardin MA, Ladoux B. Soft Matter. 2019 Apr 7;15(13):2798-2810. doi: 10.1039/c9sm00105k. Epub 2019 Mar 19.

Secreted parasite Pin1 isomerase stabilizes host PKM2 to reprogram host cell metabolism. Marsolier J, Perichon M, Weitzman JB, Medjkane S. Commun Biol. 2019 Apr 30;2:152. doi: 10.1038/s42003-019-0386-6. eCollection 2019.

Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors. Naciri I, Laisné M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O, Defossez PA. Nucleic Acids Res. 2019 Apr 23;47(7):3407-3421. doi: 10.1093/nar/gkz080.

[In-depth analysis of the relationship between the MT2 receptor of melatonin and type 2 diabetes]. Hegron A, Jockers R. Med Sci (Paris). 2019 May;35(5):412-416. doi: 10.1051/medsci/2019088. Epub 2019 May 22. French. No abstract available.

* The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium. Frapporti A, Miró Pina C, Arnaiz O, Holoch D, Kawaguchi T, Humbert A, Eleftheriou E, Lombard B, Loew D, Sperling L, Guitot K, Margueron R, Duharcourt S. Nat Commun. 2019 Jun 20;10(1):2710. doi: 10.1038/s41467-019-10648-5.

*Hyperosmotic Stress Response Memory is Modulated by Gene Positioning in Yeast. Meriem ZB, Khalil Y, Hersen P, Fabre E. Cells. 2019 Jun 13;8(6). pii: E582. doi: 10.3390/cells8060582.

Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk. Nguyen T, Duchesne L, Sankara Narayana GHN, Boggetto N, Fernig DD, Uttamrao Murade C, Ladoux B, Mège RM. Oncogene. 2019 Aug;38(35):6283-6300. doi: 10.1038/s41388-019-0875-6. Epub 2019 Jul 16.

* Expression of the Major and Pro-Oncogenic H3K9 Lysine Methyltransferase SETDB1 in Non-Small Cell Lung Cancer. Cruz-Tapias P, Zakharova V, Perez-Fernandez OM, Mantilla W, RamÍRez-Clavijo S, Ait-Si-Ali S. Cancers (Basel). 2019 Aug 8;11(8). pii: E1134. doi: 10.3390/cancers11081134.

Opposing chromatin remodelers control transcription initiation frequency and start site selection. Kubik S, Bruzzone MJ, Challal D, Dreos R, Mattarocci S, Bucher P, Libri D, Shore D. Nat Struct Mol Biol. 2019 Aug;26(8):744-754. doi: 10.1038/s41594-019-0273-3. Epub 2019 Aug 5.

Myosin II isoforms play distinct roles in adherens junction biogenesis. Heuzé ML, Sankara Narayana GHN, D’Alessandro J, Cellerin V, Dang T, Williams DS, Van Hest JC, Marcq P, Mège RM, Ladoux B. Elife. 2019 Sep 5;8. pii: e46599. doi: 10.7554/eLife.46599.

Lysine Methylation Regulators Moonlighting outside the Epigenome. Cornett EM, Ferry L, Defossez PA, Rothbart SB. Mol Cell. 2019 Sep 19;75(6):1092-1101. doi: 10.1016/j.molcel.2019.08.026. Review.

Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor. Cecon E, Dam J, Luka M, Gautier C, Chollet AM, Delagrange P, Danober L, Jockers R. Br J Pharmacol. 2019 Sep;176(18):3475-3488. doi: 10.1111/bph.14688. Epub 2019 May 20.

* Morphology of the Denisovan phalanx closer to modern humans than to Neanderthals. Bennett EA, Crevecoeur I, Viola B, Derevianko AP, Shunkov MV, Grange T, Maureille B, Geigl EM. Sci Adv. 2019 Sep 4;5(9):eaaw3950. doi: 10.1126/sciadv.aaw3950. eCollection 2019 Sep. PMID: 31517046

* The H3K9 Methylation Writer SETDB1 and its Reader MPP8 Cooperate to Silence Satellite DNA Repeats in Mouse Embryonic Stem Cells. Cruz-Tapias P, Robin P, Pontis J, Maestro LD, Ait-Si-Ali S. Genes (Basel). 2019 Sep 25;10(10). pii: E750. doi: 10.3390/genes10100750.

The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network. Codato R, Perichon M, Divol A, Fung E, Sotiropoulos A, Bigot A, Weitzman JB, Medjkane S. Sci Rep. 2019 Nov 21;9(1):17298. doi: 10.1038/s41598-019-53577-5.

* A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Casanova M, Moscatelli M, Chauvière LÉ, Huret C, Samson J, Liyakat Ali TM, Rosspopoff O, Rougeulle C. Nat Commun. 2019 Dec 11;10(1):5652. doi: 10.1038/s41467-019-13551-1.

Mutations in the TaPIN1 peptidyl prolyl isomerase gene in Theileria annulata parasites isolated in Sudan. Salim B, Chatanga E, Jannot G, Mossaad E, Nakao R, Weitzman JB. Int J Parasitol Drugs Drug Resist. 2019 Dec;11:101-105. doi: 10.1016/j.ijpddr.2019.11.001. Epub 2019 Nov 26.

Epigenetic Metaphors: An Interdisciplinary Translation of Encoding and Decoding. Raz A, Pontarotti G, Weitzman JB. New Genetics & Society 2019; 38:264-288

The emergence of form in the history of epigenetics. Weitzman JB. In: The Explosion of Life Forms (Form, function and transformation of living beings). Eds G Chapouthier and MC Maurel. ISTE Science Publishing (2019)

Methods to Investigate the Nucleocytoplasmic Shuttling Properties of β-Arrestins. Blondel-Tepaz E, Guilbert T, Scott MGH. Methods Mol Biol. 2019;1957:251-269. doi: 10.1007/978-1-4939-9158-7_16.

β-Arrestins: Multitask Scaffolds Orchestrating the Where and When in Cell Signalling. Laporte SA, Scott MGH. Methods Mol Biol. 2019;1957:9-55. doi: 10.1007/978-1-4939-9158-7_2. Review.

Les rêves typiques : témoignage d’une résistance anti-traumatique. Villa F. In : Le traumatisme : engagement et créativité du thérapeute, Tigrane Tovmassian L, Schwering K-L, Eds In Press (2019)

Publications 2018

QuantumClone: Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction. Deveau P, Colmet Daage L, Oldridge D, Bernard V, Bellini A, Chicard M, Clement N, Lapouble E, Combaret V, Boland A, Meyer V, Deleuze JF, Janoueix-Lerosey I, Barillot E, Delattre O, Maris J, Schleiermacher G, Boeva V. Bioinformatics. 2018 Jan 12. doi: 10.1093/bioinformatics/bty016.

Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis. Lopez-Delisle L, Pierre-Eugène C, Louis-Brennetot C, Surdez D, Raynal V, Baulande S, Boeva V, Grossetête-Lalami S, Combaret V, Peuchmaur M, Delattre O, Janoueix-Lerosey I. Oncogene. 2018 Jan 11. doi: 10.1038/s41388-017-0039-5.

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Kilens S, Meistermann D, Moreno D, Chariau C, Gaignerie A, Reignier A, Lelièvre Y, Casanova M, Vallot C, Nedellec S, Flippe L, Firmin J, Song J, Charpentier E, Lammers J, Donnart A, Marec N, Deb W, Bihouée A, Le Caignec C, Pecqueur C, Redon R, Barrière P, Bourdon J, Pasque V, Soumillon M, Mikkelsen TS, Rougeulle C, Fréour T, David L; Milieu Intérieur Consortium. Nat Commun. 2018 Jan 24;9(1):360. doi: 10.1038/s41467-017-02107-w.

From dynamic chromatin architecture to DNA damage repair and back. Fabre E, Zimmer C. Nucleus. 2018 Jan 1;9(1):161-170. doi: 10.1080/19491034.2017.1419847.

Force-dependent binding of vinculin to α-catenin regulates cell-cell contact stability and collective cell behavior. Seddiki R, Narayana GHNS, Strale PO, Balcioglu HE, Peyret G, Yao M, Le AP, Teck Lim C, Yan J, Ladoux B, Mège RM. Mol Biol Cell. 2018 Feb 15;29(4):380-388. doi: 10.1091/mbc.E17-04-0231. Epub 2017 Dec 27.

Srf controls satellite cell fusion through the maintenance of actin architecture. Randrianarison-Huetz V, Papaefthymiou A, Herledan G, Noviello C, Faradova U, Collard L, Pincini A, Schol E, Decaux JF, Maire P, Vassilopoulos S, Sotiropoulos A. J Cell Biol. 2018 Feb 5;217(2):685-700. doi: 10.1083/jcb.201705130. Epub 2017 Dec 21.

High-resolution transcription maps reveal the widespread impact of roadblock termination in yeast. Candelli T, Challal D, Briand JB, Boulay J, Porrua O, Colin J, Libri D. EMBO J. 2018 Feb 15;37(4). pii: e97490. doi: 10.15252/embj.201797490. Epub 2018 Jan 19. PMID: 29351914

The response to DNA damage in heterochromatin domains. Fortuny A, Polo SE. Chromosoma. 2018 Mar 29. doi: 10.1007/s00412-018-0669-6. [Epub ahead of print] Review.

* The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development. Wojciech S, Ahmad R, Belaid-Choucair Z, Journé AS, Gallet S, Dam J, Daulat A, Ndiaye-Lobry D, Lahuna O, Karamitri A, Guillaume JL, Do Cruzeiro M, Guillonneau F, Saade A, Clément N, Courivaud T, Kaabi N, Tadagaki K, Delagrange P, Prévot V, Hermine O, Prunier C, Jockers R. Nat Commun. 2018 Mar 23;9(1):1216. doi: 10.1038/s41467-018-03609-x.

A new actin-binding domain glues autophagy together. Wojnacki J, Galli T. J Biol Chem. 2018 Mar 23;293(12):4575-4576. doi: 10.1074/jbc.H118.002041.

pH sensing by lipids in membranes: The fundamentals of pH-driven migration, polarization and deformations of lipid bilayer assemblies. Angelova MI, Bitbol AF, Seigneuret M, Staneva G, Kodama A, Sakuma Y, Kawakatsu T, Imai M, Puff N. Biochim Biophys Acta. 2018 Mar 6. pii: S0005-2736(18)30067-1. doi: 10.1016/j.bbamem.2018.02.026. [Epub ahead of print] Review.

Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients. Depuydt P, Boeva V, Hocking TD, Cannoodt R, Ambros IM, Ambros PF, Asgharzadeh S, Attiyeh EF, Combaret V, Defferrari R, Fischer M, Hero B, Hogarty MD, Irwin MS, Koster J, Kreissman S, Ladenstein R, Lapouble E, Laureys G, London WB, Mazzocco K, Nakagawara A, Noguera R, Ohira M, Park JR, Pötschger U, Theissen J, Tonini GP, Valteau-Couanet D, Varesio L, Versteeg R, Speleman F, Maris JM, Schleiermacher G, De Preter K. J Natl Cancer Inst. 2018 Mar 5. doi: 10.1093/jnci/djy022.

Our Evolving Understanding of the Mechanism of Quinolones. Gutierrez A, Stokes JM, Matic I. Antibiotics (Basel). 2018 Apr 8;7(2). pii: E32. doi: 10.3390/antibiotics7020032. Review.

* Mechanical Tension Drives Elongational Growth of the Embryonic Gut. Chevalier NR, de Witte TM, Cornelissen AJM, Dufour S, Proux-Gillardeaux V, Asnacios A. Sci Rep. 2018 Apr 16;8(1):5995. doi: 10.1038/s41598-018-24368-1.

*A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits. Rouvière JO, Bulfoni M, Tuck A, Cosson B, Devaux F, Palancade B. Nat Commun. 2018 Apr 25;9(1):1665. doi: 10.1038/s41467-018-03673-3.

* The desmin network is a determinant of the cytoplasmic stiffness of myoblasts. Charrier EE, Montel L, Asnacios A, Delort F, Vicart P, Gallet F, Batonnet-Pichon S, Hénon S. Biol Cell. 2018 Apr;110(4):77-90. doi: 10.1111/boc.201700040. Epub 2018 Feb 22.

* Recurrent acquisition of cytosine methyltransferases into eukaryotic retrotransposons. de Mendoza A, Bonnet A, Vargas-Landin DB, Ji N, Li H, Yang F, Li L, Hori K, Pflueger J, Buckberry S, Ohta H, Rosic N, Lesage P, Lin S, Lister R. Nat Commun. 2018 Apr 9;9(1):1341. doi: 10.1038/s41467-018-03724-9. Erratum in: Nat Commun. 2018 May 1;9(1):1811.

* Disentangling the molecular determinants for Cenp-F localization to nuclear pores and kinetochores. Berto A, Yu J, Morchoisne-Bolhy S, Bertipaglia C, Vallee R, Dumont J, Ochsenbein F, Guerois R, Doye V. EMBO Rep. 2018 May;19(5). pii: e44742. doi: 10.15252/embr.201744742. Epub 2018 Apr 9.

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Miotto B, Marchal C, Adelmant G, Guinot N, Xie P, Marto JA, Zhang L, Defossez PA. Nucleic Acids Res. 2018 May 18;46(9):4392-4404. doi: 10.1093/nar/gky149.

Collective cell migration without proliferation: density determines cell velocity and wave velocity. Tlili S, Gauquelin E, Li B, Cardoso O, Ladoux B, Delanoë-Ayari H, Graner F. R Soc Open Sci. 2018 May 2;5(5):172421. doi: 10.1098/rsos.172421. eCollection 2018 May.

* Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells. Souquet B, Freed E, Berto A, Andric V, Audugé N, Reina-San-Martin B, Lacy E, Doye V. Cell Rep. 2018 May 22;23(8):2443-2454. doi: 10.1016/j.celrep.2018.04.070.

Biomechanical Control of Lysosomal Secretion Via the VAMP7 Hub: A Tug-of-War between VARP and LRRK1. Wang G, Nola S, Bovio S, Bun P, Coppey-Moisan M, Lafont F, Galli T. iScience. 2018 Jun 29;4:127-143. doi: 10.1016/j.isci.2018.05.016. Epub 2018 May 29.

* Heterogeneity of spontaneous DNA replication errors in single isogenic Escherichia coli cells. Woo AC, Faure L, Dapa T, Matic I. Sci Adv. 2018 Jun 20;4(6):eaat1608. doi: 10.1126/sciadv.aat1608. eCollection 2018 Jun.

A comparison of methods to assess cell mechanical properties. Wu PH, Aroush DR, Asnacios A, Chen WC, Dokukin ME, Doss BL, Durand-Smet P, Ekpenyong A, Guck J, Guz NV, Janmey PA, Lee JSH, Moore NM, Ott A, Poh YC, Ros R, Sander M, Sokolov I, Staunton JR, Wang N, Whyte G, Wirtz D. Nat Methods. 2018 Jun 18. doi: 10.1038/s41592-018-0015-1

Chromatin mobility upon DNA damage: state of the art and remaining questions. Zimmer C, Fabre E. Curr Genet. 2018 Jun 8. doi: 10.1007/s00294-018-0852-6. [Epub ahead of print] Review. PMID: 29947969

The heptad repeat domain 1 of Mitofusin has membrane destabilization function in mitochondrial fusion. Daste F, Sauvanet C, Bavdek A, Baye J, Pierre F, Le Borgne R, David C, Rojo M, Fuchs P, Tareste D. EMBO Rep. 2018 Jun;19(6). pii: e43637. doi: 10.15252/embr.201643637. Epub 2018 Apr 16.

* PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain. Gutnik S, Thomas Y, Guo Y, Stoecklin J, Neagu A, Pintard L, Merlet J, Ciosk R. Biol Open. 2018 Jul 16;7(7). pii: bio034066. doi: 10.1242/bio.034066.

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems. Piffoux M, Silva AKA, Wilhelm C, Gazeau F, Tareste D. ACS Nano. 2018 Jul 24;12(7):6830-6842. doi: 10.1021/acsnano.8b02053. Epub 2018 Jul 10.

A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key. Pintard L, Archambault V. Open Biol. 2018 Aug;8(8). pii: 180114. doi: 10.1098/rsob.180114. Review.

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume JL, Hegron A, Boissel M, Canouil M, Langenberg C, Wareham NJ, Le Gouill C, Lukasheva V, Lichtarge O, Froguel P, Bouvier M, Jockers R. Sci Signal. 2018 Aug 28;11(545). pii: eaan6622. doi: 10.1126/scisignal.aan6622.

ARAP1 Bridges Actin Dynamics and AP-3-Dependent Membrane Traffic in Bone-Digesting Osteoclasts. Segeletz S, Danglot L, Galli T, Hoflack B. iScience. 2018 Aug 31;6:199-211. doi: 10.1016/j.isci.2018.07.019. Epub 2018 Jul 26.

Strong increase in the autofluorescence of cells signals struggle for survival. Surre J, Saint-Ruf C, Collin V, Orenga S, Ramjeet M, Matic I. Sci Rep. 2018 Aug 14;8(1):12088. doi: 10.1038/s41598-018-30623-2. PMID: 30108248

The Challenges of Genome-Wide Studies in a Unicellular Eukaryote With Two Nuclear Genomes. Duharcourt S, Sperling L. Methods Enzymol. 2018;612:101-126. doi: 10.1016/bs.mie.2018.08.012. Epub 2018 Aug 31. PMID: 30502938

Genome-Wide Mapping of Yeast Retrotransposon Integration Target Sites. Barkova A, Asif-Laidin A, Lesage P. Methods Enzymol. 2018;612:197-223. doi: 10.1016/bs.mie.2018.08.002. Epub 2018 Sep 13.

* Regulation of Cenp-F localization to nuclear pores and kinetochores. Berto A, Doye V. Cell Cycle. 2018;17(17):2122-2133. doi: 10.1080/15384101.2018.1520569. Epub 2018 Sep 20.

Antibiotic-Induced Genetic Variation: How It Arises and How It Can Be Prevented. Blázquez J, Rodríguez-Beltrán J, Matic I. Annu Rev Microbiol. 2018 Sep 8;72:209-230. doi: 10.1146/annurev-micro-090817-062139.

* The first digestive movements in the embryo are mediated by mechanosensitive smooth muscle calcium waves. Chevalier NR. Philos Trans R Soc Lond B Biol Sci. 2018 Sep 24;373(1759). pii: 20170322. doi: 10.1098/rstb.2017.0322. PMID: 30249773

Developmental Epigenetics: Phenotype and the Flexible Epigenome. John RM, Rougeulle C. Front Cell Dev Biol. 2018 Oct 11;6:130. doi: 10.3389/fcell.2018.00130. eCollection 2018.

Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation. Marchal C, de Dieuleveult M, Saint-Ruf C, Guinot N, Ferry L, Olalla Saad ST, Lazarini M, Defossez PA, Miotto B. Oncogenesis. 2018 Oct 11;7(10):82. doi: 10.1038/s41389-018-0092-0.

Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change. Nagy O, Nuez I, Savisaar R, Peluffo AE, Yassin A, Lang M, Stern DL, Matute DR, David JR, Courtier-Orgogozo V. Curr Biol. 2018 Nov 5;28(21):3450-3457.e13. doi: 10.1016/j.cub.2018.08.047. Epub 2018 Oct 18.

Kalman Inversion Stress Microscopy. Nier V, Peyret G, d’Alessandro J, Ishihara S, Ladoux B, Marcq P. Biophys J. 2018 Nov 6;115(9):1808-1816. doi: 10.1016/j.bpj.2018.09.013. Epub 2018 Sep 25.

Biological Tissues as Active Nematic Liquid Crystals. Saw TB, Xi W, Ladoux B, Lim CT. Adv Mater. 2018 Nov;30(47):e1802579. doi: 10.1002/adma.201802579. Epub 2018 Aug 29. Review.

DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38. de Dieuleveult M, Miotto B. Epigenet Insights. 2018 Nov 19;11:2516865718811117. doi: 10.1177/2516865718811117. eCollection 2018.

The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage. Piquet S, Le Parc F, Bai SK, Chevallier O, Adam S, Polo SE. Mol Cell. 2018 Dec 6;72(5):888-901.e7. doi: 10.1016/j.molcel.2018.09.010. Epub 2018 Oct 18.

Mechanical forces in cell monolayers. Chen T, Saw TB, Mège RM, Ladoux B. J Cell Sci. 2018 Dec 20;131(24). pii: jcs218156. doi: 10.1242/jcs.218156. Review.

* General Regulatory Factors Control the Fidelity of Transcription by Restricting Non-coding and Ectopic Initiation. Challal D, Barucco M, Kubik S, Feuerbach F, Candelli T, Geoffroy H, Benaksas C, Shore D, Libri D. Mol Cell. 2018 Dec 20;72(6):955-969.e7. doi: 10.1016/j.molcel.2018.11.037.

Pervasive transcription fine-tunes replication origin activity. Candelli T, Gros J, Libri D. Elife. 2018 Dec 17;7. pii: e40802. doi: 10.7554/eLife.40802.

* Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure. Benleulmi-Chaachoua A, Hegron A, Le Boulch M, Karamitri A, Wierzbicka M, Wong V, Stagljar I, Delagrange P, Ahmad R, Jockers R. Cell Mol Life Sci. 2018 Dec;75(23):4357-4370. doi: 10.1007/s00018-018-2876-y. Epub 2018 Jul 24.

Mechanisms of DNA Methyltransferase Recruitment in Mammals. Laisné M, Gupta N, Kirsh O, Pradhan S, Defossez PA. Genes (Basel). 2018 Dec 10;9(12). pii: E617. doi: 10.3390/genes9120617. Review.

Method for detecting and studying genome-wide mutations in single living cells in real-time. Elez M, Robert L and Matic I. In « Series Methods in Molecular Biology: Antibiotic Resistance Protocols, Third Edition » (S.H. Gillespie, ed.), Springer 2018. 1736:29-39.

Tubular microscaffolds for studying collective cell migration. Xi W, Sonam S, Teck Lim C, Ladoux B. In «Methods in Cell Biology», Elsevier 2018.

Live Imaging of Parental Histone Variant Dynamics in UVC-Damaged Chromatin. Dabin J, Fortuny A, Piquet S, Polo SE. Methods Mol Biol. 2018;1832:243-253. doi: 10.1007/978-1-4939-8663-7_13.

Nuclear Pore Complexes in DNA Repair and Telomere Maintenance. Simon MN, Kalousi A, Soutoglou E, Géli V, Dargemont C. In: D’Angelo M. (eds) Nuclear Pore Complexes in Genome Organization, Function and Maintenance. Springer, Cham 2018.

* A Lacanian Approach to Medical Demand, With a Focus on Pediatric Genetics: A Plea for Subjectivization. Potier R, and Putois O. Front. Psychol. 2018 Nov ; 9(2021). doi : 10.3389/fpsyg.2018.02021

Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function. Oishi A, Cecon E, Jockers R. Int Rev Cell Mol Biol. 2018;338:59-77. doi: 10.1016/bs.ircmb.2018.02.002. Epub 2018 Apr 5. Review.

Publications 2017

XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development. Vallot C, Patrat C, Collier AJ, Huret C, Casanova M, Liyakat Ali TM, Tosolini M, Frydman N, Heard E, Rugg-Gunn PJ, Rougeulle C. Cell Stem Cell. 2017 Jan 5;20(1):102-111. doi: 10.1016/j.stem.2016.10.014. Epub 2016 Dec 15.

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity. Salomon J, Gaston C, Magescas J, Duvauchelle B, Canioni D, Sengmanivong L, Mayeux A, Michaux G, Campeotto F, Lemale J, Viala J, Poirier F, Minc N, Schmitz J, Brousse N, Ladoux B, Goulet O, Delacour D. Nat Commun. 2017 Jan 13;8:13998. doi: 10.1038/ncomms13998.

* Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis. Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA. Cancer Res. 2017 Jan 1;77(1):62-73. doi: 10.1158/0008-5472.CAN-16-1181. Epub 2016 Nov 4.

Long-term tracking of budding yeast cells in brightfield microscopy: CellStar and the Evaluation Platform. Versari C, Stoma S, Batmanov K, Llamosi A, Mroz F, Kaczmarek A, Deyell M, Lhoussaine C, Hersen P, Batt G. J R Soc Interface. 2017 Feb;14(127). pii: 20160705. doi: 10.1098/rsif.2016.0705.

*§ Emergence and development of gut motility in the chicken embryo. Chevalier NR, Fleury V, Dufour S, Proux-Gillardeaux V, Asnacios A. PLoS One. 2017 Feb 21;12(2):e0172511. doi: 10.1371/journal.pone.0172511. eCollection 2017.

The Notch pathway in the annelid Platynereis: insights into chaetogenesis and neurogenesis processes. Gazave E, Lemaître QI, Balavoine G. Open Biol. 2017 Feb;7(2). pii: 160242. doi: 10.1098/rsob.160242.

* [What makes a parasite « transforming »? Insights into cancer from the agents of an exotic pathology, Theileria spp]. Cheeseman KM, Weitzman JB. Bull Soc Pathol Exot. 2017 Feb;110(1):55-60. doi: 10.1007/s13149-017-0551-4. Epub 2017 Feb 2. Review. French.

Flow cytometry sorting of nuclei enables the first global characterization of Paramecium germline DNA and transposable elements. Guérin F, Arnaiz O, Boggetto N, Denby Wilkes C, Meyer E, Sperling L, Duharcourt S. BMC Genomics. 2017 Apr 26;18(1):327. doi: 10.1186/s12864-017-3713-7.

Choreography of parental histones in damaged chromatin. Dabin J, Polo SE. Nucleus. 2017 May 4;8(3):255-260. doi: 10.1080/19491034.2017.1292192. Epub 2017 Feb 23.

Integration site selection by retroviruses and transposable elements in eukaryotes. Sultana T, Zamborlini A, Cristofari G, Lesage P. Nat Rev Genet. 2017 May;18(5):292-308. doi: 10.1038/nrg.2017.7. Epub 2017 Mar 13. Review.

Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription. Patitucci C, Couchy G, Bagattin A, Cañeque T, de Reyniès A, Scoazec JY, Rodriguez R, Pontoglio M, Zucman-Rossi J, Pende M, Panasyuk G. J Clin Invest. 2017 May 1;127(5):1873-1888. doi: 10.1172/JCI90327. Epub 2017 Apr 10.

Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I. Mol Syst Biol. 2017 Mar 15;13(3):918. doi: 10.15252/msb.20167430.

Taming the late Quaternary phylogeography of the Eurasiatic wild ass through ancient and modern DNA. Bennett EA, Champlot S, Peters J, Arbuckle BS, Guimaraes S, Pruvost M, Bar-David S, Davis SJM, Gautier M, Kaczensky P, Kuehn R, Mashkour M, Morales-Muñiz A, Pucher E, Tournepiche JF, Uerpmann HP, Bălăşescu A, Germonpré M, Gündem CY, Hemami MR, Moullé PE, Ötzan A, Uerpmann M, Walzer C, Grange T, Geigl EM. PLoS One. 2017 Apr 19;12(4):e0174216. doi: 10.1371/journal.pone.0174216. eCollection 2017. PMID: 28422966 Free PMC Article

Inferring the physical properties of yeast chromatin through Bayesian analysis of whole nucleus simulations. Arbona JM, Herbert S, Fabre E, Zimmer C. Genome Biol. 2017 May 3;18(1):81. doi: 10.1186/s13059-017-1199-x.

The Emerging Role of the Cytoskeleton in Chromosome Dynamics. Spichal M, Fabre E. Front Genet. 2017 May 19;8:60. doi: 10.3389/fgene.2017.00060. eCollection 2017. Review.

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity. Saitakis M, Dogniaux S, Goudot C, Bufi N, Asnacios S, Maurin M, Randriamampita C, Asnacios A, Hivroz C. Elife. 2017 Jun 8;6. pii: e23190. doi: 10.7554/eLife.23190.

Centrin diversity and basal body patterning across evolution: new insights from Paramecium. Aubusson-Fleury A, Balavoine G, Lemullois M, Bouhouche K, Beisson J, Koll F. Biol Open. 2017 Jun 15;6(6):765-776. doi: 10.1242/bio.024273. PMID: 28432105 Free PMC Article

* SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation. Moretti C, Serrentino ME, Ialy-Radio C, Delessard M, Soboleva TA, Tores F, Leduc M, Nitschké P, Drevet JR, Tremethick DJ, Vaiman D, Kocer A, Cocquet J. Cell Death Differ. 2017 Jun;24(6):1029-1044. doi: 10.1038/cdd.2017.32. Epub 2017 May 5.

The SOS and RpoS Regulons Contribute to Bacterial Cell Robustness to Genotoxic Stress by Synergistically Regulating DNA Polymerase Pol II. Dapa T, Fleurier S, Bredeche MF, Matic I. Genetics. 2017 Jul;206(3):1349-1360. doi: 10.1534/genetics.116.199471. Epub 2017 May 3.

Design and validation of the first cell-impermeant melatonin receptor agonist. Gbahou F, Cecon E, Viault G, Gerbier R, Jean-Alphonse F, Karamitri A, Guillaumet G, Delagrange P, Friedlander RM, Vilardaga JP, Suzenet F, Jockers R. Br J Pharmacol. 2017 Jul;174(14):2409-2421. doi: 10.1111/bph.13856. Epub 2017 Jun 11.

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex. Javadi A, Deevi RK, Evergren E, Blondel-Tepaz E, Baillie GS, Scott MG, Campbell FC. Elife. 2017 Jul 27;6. pii: e24578. doi: 10.7554/eLife.24578.

Melatonin receptors: molecular pharmacology and signalling in the context of system bias. Cecon E, Oishi A, Jockers R. Br J Pharmacol. 2017 Jul 13. doi: 10.1111/bph.13950. [Epub ahead of print] Review.

Novel functions for chromatin dynamics in mRNA biogenesis beyond transcription. Dargemont C, Babour A. Nucleus. 2017 Aug 17:0. doi: 10.1080/19491034.2017.1342916. [Epub ahead of print]

Nuclear envelope: a new frontier in plant mechanosensing? Fal K, Asnacios A, Chabouté ME, Hamant O. Biophys Rev. 2017 Aug 12. doi: 10.1007/s12551-017-0302-6. [Epub ahead of print] Review.

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA. Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.

Estimation of turgor pressure through comparison between single plant cell and pressurized shell mechanics. Durand-Smet P, Gauquelin E, Chastrette N, Boudaoud A, Asnacios A. Phys Biol. 2017 Aug 16;14(5):055002. doi: 10.1088/1478-3975/aa7f30.

* Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. Oishi A, Karamitri A, Gerbier R, Lahuna O, Ahmad R, Jockers R. Sci Rep. 2017 Aug 21;7(1):8990. doi: 10.1038/s41598-017-08996-7.

[The congenital tufting enteropathy, or when the intestine is under low cellular tension]. Gaston C, Salomon J, Goulet O, Delacour D. Med Sci (Paris). 2017 Aug-Sep;33(8-9):694-697. doi: 10.1051/medsci/20173308003. Epub 2017 Sep 18. French. No abstract available. PMID: 28945548

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. Boeva V, Louis-Brennetot C, Peltier A, Durand S, Pierre-Eugène C, Raynal V, Etchevers HC, Thomas S, Lermine A, Daudigeos-Dubus E, Geoerger B, Orth MF, Grünewald TGP, Diaz E, Ducos B, Surdez D, Carcaboso AM, Medvedeva I, Deller T, Combaret V, Lapouble E, Pierron G, Grossetête-Lalami S, Baulande S, Schleiermacher G, Barillot E, Rohrer H, Delattre O, Janoueix-Lerosey I. Nat Genet. 2017 Sep;49(9):1408-1413. doi: 10.1038/ng.3921. Epub 2017 Jul 24.

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5. Review

Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast. Herbert S, Brion A, Arbona JM, Lelek M, Veillet A, Lelandais B, Parmar J, Fernández FG, Almayrac E, Khalil Y, Birgy E, Fabre E, Zimmer C. EMBO J. 2017 Sep 1;36(17):2595-2608. doi: 10.15252/embj.201695842. Epub 2017 Jul 10.

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50. Clement N, Renault N, Guillaume JL, Cecon E, Journé AS, Laurent X, Tadagaki K, Cogé F, Gohier A, Delagrange P, Chavatte P, Jockers R. Br J Pharmacol. 2017 Sep 12. doi: 10.1111/bph.14029. [Epub ahead of print]

The chromatin remodeling Isw1a complex is regulated by SUMOylation. Shen Q, Beyrouthy N, Matabishi-Bibi L, Dargemont C. Biochem J. 2017 Oct 5;474(20):3455-3469. doi: 10.1042/BCJ20170172.

§ Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Martino L, Morchoisne-Bolhy S, Cheerambathur DK, Van Hove L, Dumont J, Joly N, Desai A, Doye V, Pintard L. Dev Cell. 2017 Oct 23;43(2):157-171.e7. doi: 10.1016/j.devcel.2017.09.019.

The major contribution of the DNA damage-triggered reactive oxygen species production to cell death: implications for antimicrobial and cancer therapy. Matic I. Curr Genet. 2017 Nov 27. doi: 10.1007/s00294-017-0787-3. [Epub ahead of print] Review.

Emergent patterns of collective cell migration under tubular confinement. Xi W, Sonam S, Beng Saw T, Ladoux B, Teck Lim C. Nat Commun. 2017 Nov 15;8(1):1517. doi: 10.1038/s41467-017-01390-x. PMID: 29142242 Free PMC Article

Maladaptive DNA repair is the ultimate contributor to the death of trimethoprim-treated cells under aerobic and anaerobic conditions. Giroux X, Su WL, Bredeche MF, Matic I. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11512-11517. doi: 10.1073/pnas.1706236114. Epub 2017 Oct 9.

* M. Montévil. « A primer on mathematical modeling in the study of organisms and their parts ». In : Conceptual and Methodological challenges in Systems Biology. Sous la dir. de M. Bizzarri. T. X. Methods in Molecular Biology. Springer, 2017.

J. Gayon & M. Montévil. « Repetition and Reversibility in Evolution : Theoretical Population Genetics ». In : Time in nature and the nature of time. Sous la dir. de C. Bouton & P. Huneman. T. 326. Boston Studies in the Philosophy and History of Science. Springer, 2017.

Tandem Affinity Purification Approach Coupled to Mass Spectrometry to Identify Post-translational Modifications of Histones Associated with Chromatin-Binding Proteins. Beyer S, Robin P, Ait-Si-Ali S. Methods Mol Biol. 2017;1507:13-21.

* Epigenetics: a way to bridge the gap between biological field. Nicoglou A, Merlin F. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences. 2017; 66: 73–82.

* The role of the concept of plasticity in the history of the nature-nurture debate. Nicoglou A. In: Meloni M., Cromby J., Fitzgerald D., Lloyd S. (eds.), Handbook of Biology and Society, Palgrave, 2017: 97–122.

* The Timing of Development. Nicoglou A. In: Bouton C. & Huneman P. (eds.), Time of Nature and the Nature of Time, Boston Studies in the Philosophy and History of Science, 2017: vol 326, Springer, Cham, 359–390.

* Depersonalization : clinical and nosographic ambiguities. Troubé S. L’évolution psychiatrique 2017; 82: 817-828.

MITF – A controls branching morphogenesis and nephron endowment. Phelep A, Laouari D, Bharti K, Burtin M, Tammaccaro S, Garbay S, Nguyen C, Vasseur F, Blanc T, Berissi S, Langa-Vives F, Fischer E, Druilhe A, Arnheiter H, Friedlander G, Pontoglio M, Terzi F. PLoS Genet. 2017 Dec 14;13(12):e1007093. doi: 10.1371/journal.pgen.1007093. eCollection 2017 Dec. PMID: 29240767

* Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii. Özpolat BD, Handberg-Thorsager M, Vervoort M, Balavoine G. Elife. 2017 Dec 12;6. pii: e30463. doi: 10.7554/eLife.30463. PMID: 29231816

Mechanobiology of collective cell behaviours. Ladoux B, Mège RM. Nat Rev Mol Cell Biol. 2017 Dec;18(12):743-757. doi: 10.1038/nrm.2017.98. Epub 2017 Nov 8. Review. PMID: 29115298

Yeast nucleus: a model for chromatin folding principles. Almayrac E & Fabre E. In Nuclear Architecture and Dynamics, 2017, Lavelle C & Victor J-M (eds)

Publications 2016

§ Posttranslational marks control architectural and functional plasticity of the nuclear pore complex basket. Niño CA, Guet D, Gay A, Brutus S, Jourquin F, Mendiratta S, Salamero J, Géli V, Dargemont C. J Cell Biol. 2016 Jan 18;212(2):167-80. doi: 10.1083/jcb.201506130.

* Water jet indentation for local elasticity measurements of soft materials. Chevalier NR, Dantan P, Gazquez E, Cornelissen AJ, Fleury V. Eur Phys J E Soft Matter. 2016 Jan;39 (1):10. doi: 10.1140/epje/i2016-16010-1.

* Desmin Mutation in the C-Terminal Domain Impairs Traction Force Generation in Myoblasts. Charrier EE, Asnacios A, Milloud R, De Mets R, Balland M, Delort F, Cardoso O, Vicart P, Batonnet-Pichon S, Hénon S. Biophys J. 2016 Jan 19;110(2):470-80. doi: 10.1016/j.bpj.2015.11.3518.

Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia. Ducat A, Doridot L, Calicchio R, Méhats C, Vilotte JL, Castille J, Barbaux S, Couderc B, Jacques S, Letourneur F, Buffat C, Le Grand F, Laissue P, Miralles F, Vaiman D. Sci Rep. 2016 Jan 13;6:19196. doi: 10.1038/srep19196.

Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Wright DG, Marchal C, Hoang K, Ankney JA, Nguyen ST, Rushing AW, Polakowski N, Miotto B, Lemasson I. Oncotarget. 2016 Jan 12;7(2):1687-706. doi: 10.18632/oncotarget.6424.

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB, Darmon M, Espin A, Stagljar I, Tafelmeyer P, Zamponi GW, Delagrange P, Maurice P, Jockers R. J Pineal Res. 2016 Jan;60(1):95-108. doi: 10.1111/jpi.12294.

* Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes. Delépine C, Meziane H, Nectoux J, Opitz M, Smith AB, Ballatore C, Saillour Y, Bennaceur-Griscelli A, Chang Q, Williams EC, Dahan M, Duboin A, Billuart P, Herault Y, Bienvenu T. Hum Mol Genet. 2016 Jan 1;25(1):146-57. doi: 10.1093/hmg/ddv464.

* Measuring the micromechanical properties of embryonic tissues. Chevalier NR, Gazguez E, Dufour S, Fleury V. Methods. 2016 Feb 1;94:120-8. doi: 10.1016/j.ymeth.2015.08.001.

* DNA deletion as a mechanism for developmentally programmed centromere loss. Lhuillier-Akakpo M, Guérin F, Frapporti A, Duharcourt S. Nucleic Acids Res. 2016 Feb 29;44(4):1553-65. doi: 10.1093/nar/gkv1110.

§ [Regards croisés sur une pathologie développementale d’origine génétique. Réflexions épistémologiques et cliniques sur l’impact psychique du syndrome de microdélétion 22q11.2] Potier R, Putois O, Lyonnet S, Weitzman JB, Villa F. Topique 2016/2 (n° 135), p. 103-117. DOI 10.3917/top.135.0103.

* What Population Reveals about Individual Cell Identity: Single-Cell Parameter Estimation of Models of Gene Expression in Yeast. Llamosi A, Gonzalez-Vargas AM, Versari C, Cinquemani E, Ferrari-Trecate G, Hersen P, Batt G. PLoS Comput Biol. 2016 Feb 9;12(2):e1004706. doi: 10.1371/journal.pcbi.1004706.

Evidence for a dual role of actin in regulating chromosome organization and dynamics in yeast. Spichal M, Brion A, Herbert S, Cournac A, Marbouty M, Zimmer C, Koszul R, Fabre E. J Cell Sci. 2016 Feb 15;129(4):681-92. doi: 10.1242/jcs.175745.

Plasticity of the brush border – the yin and yang of intestinal homeostasis. Delacour D, Salomon J, Robine S, Louvard D. Nat Rev Gastroenterol Hepatol. 2016 Mar;13(3):161-74. doi: 10.1038/nrgastro.2016.5. Epub 2016 Feb 3. Review.

Evolution of Prdm Genes in Animals: Insights from Comparative Genomics. Vervoort M, Meulemeester D, Béhague J, Kerner P. Mol Biol Evol. 2016 Mar;33(3):679-96. doi: 10.1093/molbev/msv260.

Remodeling the zonula adherens in response to tension and the role of afadin in this response. Choi W, Acharya BR, Peyret G, Fardin MA, Mège RM, Ladoux B, Yap AS, Fanning AS, Peifer M. J Cell Biol. 2016 Apr 25;213(2):243-60. doi: 10.1083/jcb.201506115.

Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells. Thomas Y, Cirillo L, Panbianco C, Martino L, Tavernier N, Schwager F, Van Hove L, Joly N, Santamaria A, Pintard L, Gotta M. Cell Rep. 2016 Apr 19;15(3):510-8. doi: 10.1016/j.celrep.2016.03.049.

* Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry. Boyarchuk E, Robin P, Fritsch L, Joliot V, Ait-Si-Ali S. J Vis Exp. 2016 May 17;(111). doi: 10.3791/53924.

Epigenome Maintenance in Response to DNA Damage. Dabin J, Fortuny A, Polo SE. Mol Cell. 2016 Jun 2;62(5):712-27. doi: 10.1016/j.molcel.2016.04.006. Review.

* Unexpected Distinct Roles of the Related Histone H3 Lysine 9 Methyltransferases G9a and G9a-Like Protein in Myoblasts. Battisti V, Pontis J, Boyarchuk E, Fritsch L, Robin P, Ait-Si-Ali S, Joliot V. J Mol Biol. 2016 Jun 5;428(11):2329-43. doi: 10.1016/j.jmb.2016.03.029.

Antibiotic Susceptibility Testing of the Gram-Negative Bacteria Based on Flow Cytometry. Saint-Ruf C, Crussard S, Franceschi C, Orenga S, Ouattara J, Ramjeet M, Surre J, Matic I. Front Microbiol. 2016 Jul 26;7:1121. doi: 10.3389/fmicb.2016.01121.

A cost-effective high-throughput metabarcoding approach powerful enough to genotype ~44 000 year-old rodent remains from Northern Africa. Guimaraes S, Pruvost M, Daligault J, Stoetzel E, Bennett EA, Côté NM, Nicolas V, Lalis A, Denys C, Geigl EM, Grange T. Mol Ecol Resour. 2016 Jul 4. doi: 10.1111/1755-0998.12565. [Epub ahead of print] PMID: 27374145

Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics. Mathieu A, Fleurier S, Frénoy A, Dairou J, Bredeche MF, Sanchez-Vizuete P, Song X, Matic I. Cell Rep. 2016 Sep 27;17(1):46-57. doi: 10.1016/j.celrep.2016.09.001.

Human mutations affect the epigenetic/bookmarking function of HNF1B. Lerner J, Bagattin A, Verdeguer F, Makinistoglu MP, Garbay S, Felix T, Heidet L, Pontoglio M. Nucleic Acids Res. 2016 Sep 30;44(17):8097-111. doi: 10.1093/nar/gkw467.

A suppressor locus for MODY3-diabetes. Garcia-Gonzalez MA, Carette C, Bagattin A, Chiral M, Makinistoglu MP, Garbay S, Prévost G, Madaras C, Hérault Y, Leibovici M, Pontoglio M. Sci Rep. 2016 Sep 26;6:33087. doi: 10.1038/srep33087.

§ Update on melatonin receptors: IUPHAR Review 20. Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP. Br J Pharmacol. 2016 Sep;173(18):2702-25. doi: 10.1111/bph.13536. Review.

Mechanics of epithelial tissues during gap closure. Begnaud S, Chen T, Delacour D, Mège RM, Ladoux B. Curr Opin Cell Biol. 2016 Oct;42:52-62. doi: 10.1016/j.ceb.2016.04.006. Review.

Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage. Adam S, Dabin J, Chevallier O, Leroy O, Baldeyron C, Corpet A, Lomonte P, Renaud O, Almouzni G, Polo SE. Mol Cell. 2016 Oct 6;64(1):65-78. doi: 10.1016/j.molcel.2016.08.019.

Conservation and divergence of bHLH genes in the calcisponge Sycon ciliatum. Fortunato SA, Vervoort M, Adamski M, Adamska M. Evodevo. 2016 Oct 14;7:23. PMID: 27757221

§ MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis. Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P. Nucleic Acids Res. 2016 Oct 14;44(18):8621-8640.

[Parasites and cancer: is there a causal link?] Cheeseman K, Certad G, Weitzman JB. Med Sci (Paris). 2016 Oct;32(10):867-873. French.

Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation. Beyer S, Pontis J, Schirwis E, Battisti V, Rudolf A, Le Grand F, Ait-Si-Ali S. Cell Discov. 2016 Oct 18;2:16037. Erratum in: Cell Discov. 2016 Nov 15;2:16043.

§ The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis. Babour A, Shen Q, Dos-Santos J, Murray S, Gay A, Challal D, Fasken M, Palancade B, Corbett A, Libri D, Mellor J, Dargemont C. Cell. 2016 Nov 17;167(5):1201-1214.e15. doi: 10.1016/j.cell.2016.10.048.

Epithelial Cell Packing Induces Distinct Modes of Cell Extrusions. Kocgozlu L, Saw TB, Le AP, Yow I, Shagirov M, Wong E, Mège RM, Lim CT, Toyama Y, Ladoux B. Curr Biol. 2016 Nov 7;26(21):2942-2950. doi: 10.1016/j.cub.2016.08.057.

* A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1. Duranteau M, Montagne JJ, Rahmani Z. Biol Open. 2016 Nov 15;5(11):1674-1679. doi: 10.1242/bio.021196.

Stat3 Controls Tubulointerstitial Communication during CKD. Bienaimé F, Muorah M, Yammine L, Burtin M, Nguyen C, Baron W, Garbay S, Viau A, Broueilh M, Blanc T, Peters D, Poli V, Anglicheau D, Friedlander G, Pontoglio M, Gallazzini M, Terzi F. J Am Soc Nephrol. 2016 Dec;27(12):3690-3705.

§ Joint denoising-deconvolution approach for fluorescence microscopy Maji S., Dargemont C., Salamero J., Boulanger J. (2016). IEEE ISBI, 2016, 128-131. 10.1109/ISBI.2016.7493227

The « Mendelian Gene » and the « Molecular Gene »: Two Relevant Concepts of Genetic Units. Orgogozo V, Peluffo AE, Morizot B. Curr Top Dev Biol. 2016;119:1-26. doi:10.1016/bs.ctdb.2016.03.002.

Analysis of Ancient DNA in Microbial Ecology. Gorgé O, Bennett EA, Massilani D, Daligault J, Pruvost M, Geigl EM, Grange T. Methods Mol Biol. 2016;1399:289-315. doi: 10.1007/978-1-4939-3369-3_17.

Mapping intracellular mechanics on micropatterned substrates. Mandal K, Asnacios A, Goud B, Manneville JB. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7159-E7168.

On the possible structural role of single chain sphingolipids Sphingosine and Sphingosine 1-phosphate in the amyloid-β peptide interactions with membranes. Consequences for Alzheimer’s disease development. C Watanabe, M Seigneuret, G Staneva, N Puff, MI Angelova. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2016, 510, 317-327

* Theoretical approach of ductal morphogenesis. Montévil M, C. Sonnenschein C, Soto AM. Journal of Theoretical and Applied Vascular Research 1.1 (2016). doi : 10.24019/jtavr.7

The biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms. Soto AM, Longo G, Montévil M, Sonnenschein C. Progress in Biophysics and Molecular Biology 122.1 (2016), p. 16–23. issn : 0079-6107. doi : 10.1016/j.pbiomolbio.2016.06.006

Theoretical principles for biology: Organization. Mossio M, Montévil M, Longo G. Progress in Biophysics and Molecular Biology 122.1 (2016), p. 24–35. issn : 0079-6107. doi : 10.1016/j.pbiomolbio.2016.07.005

* Theoretical principles for biology: Variation. Montévil M, Mossio, Pocheville A, Longo G. Progress in Biophysics and Molecular Biology 122.1 (2016), p. 36–50. issn : 0079-6107. do: 10.1016/j.pbiomolbio.2016.08.005

* Modeling mammary organogenesis from biological first principles : Cells and their physical constraints. Montévil M, Speroni L, Sonnenschein C, Soto AM. Progress in Biophysics and Molecular Biology 122.1 (2016), p. 58–69. issn: 0079-6107. doi: 10.1016/j.pbiomolbio.2016.08.004

Molecular mechanisms involved in the regulation of mutation rates in bacteria. Matic I. Periodicum Biologorum (2016), 118: 363–372.

Physics of amniote formation. Fleury V, Murukutla AV, Chevalier N, Gallois B, Capellazzi-Resta M, Pierre Picquet P and A. Peaucelle A. Phys. Rev. E, 94, 022426 (2016).

Publications 2015

§ Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Marsolier J, Perichon M, DeBarry JD, Villoutreix BO, Chluba J, Lopez T, Garrido C, Zhou XZ, Lu KP, Fritsch L, Ait-Si-Ali S, Mhadhbi M, Medjkane S, Weitzman JB. Nature. 2015 Jan 26. doi: 10.1038/nature14044.

Differential Expression and Regulation of Brain-Derived Neurotrophic Factor (BDNF) mRNA Isoforms in Brain Cells from Mecp2(308/y) Mouse Model. Rousseaud A, Delépine C, Nectoux J, Billuart P, Bienvenu T. J Mol Neurosci. 2015 Aug;56(4):758-67. doi: 10.1007/s12031-014-0487-0. Epub 2015 Jan 30.

Comment le parasite apicomplexe Theileria manipule-t-il l’identité cellulaire de son hôte bovin? Marsolier J, Weitzman JB. Biologie Aujourd’hui 2015; 208:1-13

* Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin and lipid binding. Floch AG, Tareste D, Fuchs PF, Chadrin A, Naciri I, Léger T, Schlenstedt G, Palancade B, Doye V. J Cell Sci. 2015 Jan 15;128(2):305-16. doi: 10.1242/jcs.158915. Epub 2014 Nov 20.

Mechanics of epithelial closure over non-adherent environments. Vedula SR, Peyret G, Cheddadi I, Chen T, Brugués A, Hirata H, Lopez-Menendez H, Toyama Y, Neves de Almeida L, Trepat X, Lim CT, Ladoux B. Nat Commun. 2015 Jan 22;6:6111. doi: 10.1038/ncomms7111.

A metameric origin for the annelid pygidium? Starunov VV, Dray N, Belikova EV, Kerner P, Vervoort M, Balavoine G. BMC Evolutionary Biology 2015, 15:25 doi:10.1186/s12862-015-0299-z

Reshaping chromatin after DNA damage: the choreography of histone proteins. Polo SE. J Mol Biol. 2015 Feb 13;427(3):626-36. doi: 10.1016/j.jmb.2014.05.025. Epub 2014 Jun 2. Review.

Buckling along boundaries of elastic contrast as a mechanism for early vertebrate morphogenesis. Fleury V, Chevalier NR, Furfaro F, Duband JL. Eur. Phys. J. E (2015) 38: 6. doi : 10.1140/epje/i2015-15006-7

* La revendication de la reconnaissance de l’identité devant la clinique de l’identification primaire. Putois O. Cliniques Méditerranéennes, 2015/1, p. 205-219.

* Traumatic mutuality: a figure of living the experience of cancer during childhood. Araneda M., Topique. March 2015

* Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. Tavernier N, Noatynska A, Panbianco C, Martino L, Van Hove L, Schwager F, Léger T, Gotta M, Pintard L. J Cell Biol. 2015 Mar 16;208(6):661-9. doi: 10.1083/jcb.201408064. Epub 2015 Mar 9.

Chromatin plasticity in response to DNA damage: The shape of things to come. Adam S, Dabin J, Polo SE. DNA Repair (Amst). 2015 Aug;32:120-6. doi: 10.1016/j.dnarep.2015.04.022. Epub 2015 May 1.

Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers. Kamal M, Gbahou F, Guillaume JL, Daulat AM, Benleulmi-Chaachoua A, Luka M, Chen P, Kalbasi Anaraki D, Baroncini M, Mannoury la Cour C, Millan MJ, Prevot V, Delagrange P, Jockers R. J Biol Chem. 2015 May 1;290(18):11537-46. doi: 10.1074/jbc.M114.559542. Epub 2015 Mar 13.

Structured illumination microscopy reveals focal adhesions are composed of linear subunits. Hu S, Tee YH, Kabla A, Zaidel-Bar R, Bershadsky A, Hersen P. Cytoskeleton (Hoboken). 2015 May;72(5):235-45. doi: 10.1002/cm.21223.

Human Primary Immune Cells Exhibit Distinct Mechanical Properties that Are Modified by Inflammation. Bufi N, Saitakis M, Dogniaux S, Buschinger O, Bohineust A, Richert A, Maurin M, Hivroz C, Asnacios A. Biophys J. 2015 May 5;108(9):2181-90. doi: 10.1016/j.bpj.2015.03.047.

Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway. Cecon E, Chen M, Marçola M, Fernandes PA, Jockers R, Markus RP. FASEB J. 2015 Jun;29(6):2566-82. doi: 10.1096/fj.14-265678. Epub 2015 Mar 10.

GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper. Doly S, Shirvani H, Gäta G, Meye FJ, Emerit MB, Enslen H, Achour L, Pardo-Lopez L, Yang SK, Armand V, Gardette R, Giros B, Gassmann M, Bettler B, Mameli M, Darmon M, Marullo S. Mol Psychiatry. 2015 Jun 2. doi: 10.1038/mp.2015.72. [Epub ahead of print]

* Vivre au-dessus de ses moyens et faire face au traumatisme psychique. L’une des dimensions probables de l’irreprésentable du trauma. Araneda M. Recherches en Psychanalyse. Juin 2015.

*§ Lost in post-translation. Putois O, Villa F, Weitzman JB. EMBO Rep. 2015 Jun;16(6):671. doi: 10.15252/embr.201439980. Epub 2015 Apr 16.

* The « Genetic Program »: Behind the Genesis of an Influential Metaphor. Peluffo AE. Genetics. 2015 Jul;200(3):685-96. doi: 10.1534/genetics.115.178418.

* Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora. Tavernier N, Panbianco C, Gotta M, Pintard L. Cell Cycle. 2015 Aug 3;14(15):2394-8. doi: 10.1080/15384101.2015.1053673. Epub 2015 Jun 3.

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment. Défachelles L, Hainline SG, Menant A, Lee LA, Karess RE. J Cell Sci. 2015 Aug 1;128(15):2952. doi: 10.1242/jcs.176826. No abstract available.

Sound of silence: the properties and functions of repressive Lys methyltransferases. Mozzetta C, Boyarchuk E, Pontis J, Ait-Si-Ali S. Nat Rev Mol Cell Biol. 2015 Aug;16(8):499-513. doi: 10.1038/nrm4029. Review.

EMBO workshop al fin del mundo: a meeting on membrane trafficking and its implication for polarity and diseases. Marzolo MP, Faundez V, Galli T. Biol Cell. 2015 Jul;107(7):245-8. doi: 10.1111/boc.201570100.

Host-parasite interactions: an intimate epigenetic relationship. Cheeseman K, Weitzman JB. Cell Microbiol. 2015 Aug;17(8):1121-32. doi: 10.1111/cmi.12471.

* Cell cycle timing regulation during asynchronous divisions of the early C. elegans embryo. Tavernier N, Labbé JC, Pintard L. Exp Cell Res. 2015 Oct 1;337(2):243-8. doi: 10.1016/j.yexcr.2015.07.022. Epub 2015 Jul 23. Review.

* A Major Locus Controls a Genital Shape Difference Involved in Reproductive Isolation Between Drosophila yakuba and Drosophila santomea. Peluffo AE, Nuez I, Debat V, Savisaar R, Stern DL, Orgogozo V. G3 (Bethesda). 2015 Oct 28;5(12):2893-901. doi: 10.1534/g3.115.023481.

*§ Combining Spinach-tagged RNA and gene localization to image gene expression in live yeast. Guet D, Burns LT, Maji S, Boulanger J, Hersen P, Wente SR, Salamero J, Dargemont C. Nat Commun. 2015 Nov 19;6:8882. doi: 10.1038/ncomms9882.

Imaging local deposition of newly synthesized histones in UVC-damaged chromatin. Adam S, Dabin J, Bai SK, Polo SE. Methods Mol Biol. 2015;1288:337-47. doi: 10.1007/978-1-4939-2474-5_19.

Chromatin dynamics after DNA damage: The legacy of the access-repair-restore model. Polo SE, Almouzni G. DNA Repair (Amst). 2015 Dec;36:114-21. doi: 10.1016/j.dnarep.2015.09.014. Epub 2015 Sep 15. Review.

* The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs). Kuster A, Nola S, Dingli F, Vacca B, Gauchy C, Beaujouan JC, Nunez M, Moncion T, Loew D, Formstecher E, Galli T, Proux-Gillardeaux V. J Biol Chem. 2015 Nov 20;290(47):28056-69. doi: 10.1074/jbc.M115.666362. Epub 2015 Sep 10.

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA, Bernard D. Aging (Albany NY). 2015 Nov;7(11):986-1003.

* Astrocyte Transcriptome from the Mecp2(308)-Truncated Mouse Model of Rett Syndrome. Delépine C, Nectoux J, Letourneur F, Baud V, Chelly J, Billuart P, Bienvenu T. Neuromolecular Med. 2015 Dec;17(4):353-63. doi: 10.1007/s12017-015-8363-9. Epub 2015 Jul 25.

Method for detecting and studying genome-wide mutations in single living cells in real-time. Elez, M., Robert, L., and Matic, I. (2015) In « Series Methods in Molecular Biology: Antibiotic Resistance Protocols, Third Edition » (S.H. Gillespie, ed.), Springer.

LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis. Just PA, Poncy A, Charawi S, Dahmani R, Traore M, Dumontet T, Drouet V, Dumont F, Gilgenkrantz H, Colnot S, Terris B, Coulouarn C, Lemaigre F, Perret C. PLoS One. 2015 Dec 21;10(12):e0145400. doi: 10.1371/journal.pone.0145400. eCollection 2015.

Anatomical and ultrastructural study of PRAF2 expression in the mouse central nervous system. Cifuentes-Diaz C, Marullo S, Doly S. Brain Struct Funct. 2015 Dec 8.

* Rapid detection of dynamic PTEN regulation in living cells using intramolecular BRET. Misticone S, Lima-Fernandes E, Scott MGH. In PTEN Methods and Protocols (Eds. L. Salmena & V. Stambolic) Methods Mol Biol 1388, 95-110.

* Book review: Entangled Life: Organism and Environment in the Biological and Social Sciences, Barker G., Desjardins E. & Pearce T. (eds.). Nicoglou A. History and Philosophy of the Life Sciences, 2015, Vol 37(2), pp. 222–224.

Publications 2014

Arrestins as regulatory hubs in cancer signalling pathways. Enslen H, Lima-Fernandes E, Scott MG. Handb Exp Pharmacol. 2014; 219:405-25. doi: 10.1038/ncomms5431.

Comment on « The Use of BRET to Study Receptor-Protein Interactions ». Jockers R. Front Endocrinol (Lausanne). 2014 Jan 22;5:3. doi: 10.3389/fendo.2014.00003. eCollection 2014. No abstract available.

Anti-obesity phenotypic screening looking to increase OBR cell surface expression. Kim TH, Choi DH, Vauthier V, Dam J, Li X, Nam YJ, Ko Y, Kwon HJ, Shin SH, Cechetto J, Soloveva V, Jockers R. J Biomol Screen. 2014 Jan;19(1):88-99. doi: 10.1177/1087057113499185. Epub 2013 Aug 19.

Frontiers commentary on tallet et Al. Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transfer. Jockers R. Front Endocrinol (Lausanne). 2014 Jun 18;5:88. doi: 10.3389/fendo.2014.00088. eCollection 2014.

What’s the damage? The impact of pathogens on pathways that maintain host genome integrity. Weitzman MD, Weitzman JB. Cell Host Microbe. 2014 Mar 12; 15(3):283-94. doi:10.1016/j.chom.2014.02.010.

H2B ubiquitylation modulates spliceosome assembly and function in budding yeast. Hérissant L, Moehle EA, Bertaccini D, Van Dorsselaer A, Schaeffer-Reiss C, Guthrie C, Dargemont C. Biol Cell. 2014 Apr; 106(4):126-38. doi: 10.1111/boc.201400003. Epub 2014 Feb 25.

MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress. Laget S, Miotto B, Chin HG, Estève PO, Roberts RJ, Pradhan S, Defossez PA. Epigenetics. 2014 Apr 1; 9(4):546-56. doi: 10.4161/epi.27695. Epub 2014 Jan 16.

The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman-Smook H, Pugh D, Debatisse M, He F, Zhang L, Defossez PA. Cell Rep. 2014 Apr 24;7(2):575-87. doi: 10.1016/j.celrep.2014.03.030.

G4 motifs affect origin positioning and efficiency in two vertebrate replicators. Valton AL, Hassan-Zadeh V, Lema I, Boggetto N, Alberti P, Saintomé C, Riou JF, Prioleau MN. EMBO J. 2014 Apr 1; 33(7):732-46. doi: 10.1002/embj.201387506. Epub 2014 Feb 12.

Protein-Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives. Ferré S, Casado V, Devis LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP Guitart XG. Pharma Rev, 66:413-434 (2014). doi: 10.1124/pr.113.008052. Review.

The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells. Picard F, Cadoret JC, Audit B, Arneodo A, Alberti A, Battail C, Duret L, Prioleau MN. PLoS Genet. 2014 May 1;10(5): e1004282. doi: 10.1371/journal.pgen.1004282. eCollection 2014 May.

* Fifty years of nuclear pores and nucleocytoplasmic transport studies: multiple tools revealing complex rules. Floch AG, Palancade B, Doye V. Methods Cell Biol. 2014; 122:1-40. doi: 10.1016/B978-0-12-417160-2.00001-1.

§ Growing yeast into cylindrical colonies. Vulin C, Di Meglio JM, Lindner AB, Daerr A, Murray A, Hersen P. Biophys J. 2014 May 20;106(10):2214-21. doi: 10.1016/j.bpj.2014.02.040.

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice. Gougelet A, Torre C, Veber P, Sartor C, Bachelot L, Denechaud PD, Godard C, Moldes M, Burnol AF, Dubuquoy C, Terris B, Guillonneau F, Ye T, Schwarz M, Braeuning A, Perret C, Colnot S. Hepatology. 2014 Jun;59(6):2344-57. doi: 10.1002/hep.26924.

* Library construction for ancient genomics: single strand or double strand? Bennett EA, Massilani D, Lizzo G, Daligault J, Geigl EM, Grange T. Biotechniques. 2014 Jun 1;56(6):289-90, 292-6, 298. passim. doi: 10.2144/000114176. eCollection 2014 Jun.

Blurring the line between the DNA damage response and transcription: The importance of chromatin dynamics. Adam S, Polo SE. Exp Cell Res. 2014 Nov 15;329(1):148-53. doi: 10.1016/j.yexcr.2014.07.017. Epub 2014 Jul 22. Review.

* Zero-mode waveguide detection of flow-driven DNA translocation through nanopores. Auger T, Mathé J, Viasnoff V, Charron G, Di Meglio JM, Auvray L, Montel F. Phys Rev Lett. 2014 Jul 11;113(2):028302. Epub 2014 Jul 9.

* A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells. Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MG. Nat Commun. 2014 Jul 16;5:4431. doi: 10.1038/ncomms5431.

Genetic information transfer promotes cooperation in bacteria. Dimitriu T, Lotton C, Bénard-Capelle J, Misevic D, Brown SP, Lindner AB, Taddei F. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11103-8. doi: 10.1073/pnas.1406840111. Epub 2014 Jul 14.

N1-Linked Melatonin Dimers as Bivalent Ligands Targeting Dimeric Melatonin Receptors. Journé AS, Habib SAM, Dodda BR, Morcos MNF, Sadek MS, Tadros SAA, Witt-Enderby PA, Jockers R and Zlotos DP. Med. Chem. Commun., 2014,5, 792-796. doi: 10.1039/C4MD00079J

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Bonizec M, Hérissant L, Pokrzywa W, Geng F, Wenzel S, Howard GC, Rodriguez P, Krause S, Tansey WP, Hoppe T, Dargemont C. Nucleic Acids Res. 2014;42(17):10975-86. doi: 10.1093/nar/gku786. Epub 2014 Sep 2.

Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease. Tosini G, Owino S, Guillaume JL, Jockers R. Bioessays. 2014 Aug;36(8):778-87. doi: 10.1002/bies.201400017. Epub 2014 Jun 5. Review.

History of a prolific family: the Hes/Hey-related genes of the annelid Platynereis. Gazave E, Guillou A, Balavoine G. Evodevo. 2014 Sep 5;5:29. doi: 10.1186/2041-9139-5-29. eCollection 2014.

Massive diversification in aging colonies of Escherichia coli. Saint-Ruf C, Garfa-Traoré M, Collin V, Cordier C, Franceschi C, Matic I. J Bacteriol. 2014 Sep;196(17):3059-73. doi: 10.1128/JB.01421-13. Epub 2014 Jun 30.

MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain. Baymaz HI, Fournier A, Laget S, Ji Z, Jansen PW, Smits AH, Ferry L, Mensinga A, Poser I, Sharrocks A, Defossez PA, Vermeulen M. Proteomics. 2014 Oct;14(19):2179-89. doi: 10.1002/pmic.201400013. Epub 2014 Apr 24.

§ High transcript levels of heat-shock genes are associated with shorter lifespan of Caenorhabditis elegans. Manière X, Krisko A, Pellay FX, Di Meglio JM, Hersen P, Matic I. Exp Gerontol. 2014 Dec;60:12-7. doi: 10.1016/j.exger.2014.09.005. Epub 2014 Sep 16.

[Pin1: a multi-talented peptidyl prolyl cis-trans isomerase and a promising therapeutic target for human cancers]. Pin1 : une Peptidyl Prolyl cis-trans Isomérase multifonctionnelle et une cible anticancéreuse prometteuse. Marsolier J, Weitzman JB. Med Sci (Paris). 2014 Aug-Sep;30(8-9):772-8. doi: 10.1051/medsci/20143008015. Epub 2014 Sep 1. Review. French

*§ Local Effect of Enhancer of Zeste-Like Reveals Cooperation of Epigenetic and cis-Acting Determinants for Zygotic Genome Rearrangements. Lhuillier-Akakpo M, Frapporti A, Denby Wilkes C, Matelot M, Vervoort M, Sperling L, Duharcourt S. PLoS Genet. 2014 Sep 25;10(9):e1004665. doi: 10.1371/journal.pgen.1004665. eCollection 2014.

The SWI/SNF Subunit/Tumor Suppressor BAF47/INI1 Is Essential in Cell Cycle Arrest upon Skeletal Muscle Terminal Differentiation. Joliot V, Ait-Mohamed O, Battisti V, Pontis J, Philipot O, Robin P, Ito H, Ait-Si-Ali S. PLoS One. 2014 Oct 1;9(10):e108858. doi: 10.1371/journal.pone.0108858. eCollection 2014.

New pharmacological perspectives for the leptin receptor in the treatment of obesity. Roujeau C, Jockers R, Dam J. Front Endocrinol (Lausanne). 2014 Oct 13;5:167. doi: 10.3389/fendo.2014.00167. Review

Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2. Mozzetta C, Pontis J, Ait-Si-Ali S. Antioxid Redox Signal. 2014 Nov 3.

* Post-implantation rehabilitation: a psychic translation?, Translation as Innovation. Bridging the Sciences and the Humanities. Potier R, Putois O. Dalkey Archive Press (Champaign, USA) 2014.

* The body as a refuge, the refuge as a witness. A figure of the body in the work of Aharon Appelfeld. Araneda M, Villa F. Champ psychosomatique. 2014 Dec. – n° 66, p. 121-133.

Nuclear actin and myocardin-related transcription factors control disuse muscle atrophy through regulation of Srf activity. Collard L, Herledan G, Pincini A, Guerci A, Randrianarison-Huetz V, Sotiropoulos A. J Cell Sci. 2014 Dec 15;127(24):5157-63. doi: 10.1242/jcs.155911. Epub 2014 Oct 24.

Segment formation in Annelids: patterns, processes and evolution. Balavoine G. Int J Dev Biol. 2014;58(6-7-8):469-483.

The Psychoanalytical Method and the Disaster of Totalitarianism: Borderline States as the Psychical Equivalent of the Discontent in Civilization? Villa F., Critical Inquiry Winter 2014, 40-2, 267-287.

* Phenotypic plasticity: from microevolution to macroevolution. Nicoglou A. In : Heams T., Huneman P., Lecointre G., Silberstein M. (eds), Handbook of Evolution Theory in the Sciences, 2014, Dordrecht : Springer, pp. 285 –318.

* Générer la forme en biologie : une caractéristique du processus développemental. Nicoglou A. Chapitre 16 dans : Hoquet T. & Merlin F. (eds), Précis de Philosophie de la Biologie, 2014, Paris : Vuibert, pp. 221–235.

Comparison of animal and plant development: a right track to establish a theory of development? Vervoort M. (2014). In Towards a Theory of Development , ed. A. Minelli and T. Pradeu, Oxford University Press.

Publications 2013

New insights into the role of BubR1 in mitosis and beyond. Karess RE, Wassmann K, Rahmani Z. Int Rev Cell Mol Biol. 2013;306:223-73. doi: 10.1016/B978-0-12-407694-5.00006-7. Review.

On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA, Defossez PA. Epigenetics. 2013 Feb; 8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16. Review.

Bacterial responses and genome instability induced by subinhibitory concentrations of antibiotics. Laureti L, Matic, I, and Gutierrez, A. Antibiotics. 2013, 2:100-114. doi:10.3390/antibiotics2010100

* «Vision et Narcissisme» La théorie de la vision du dernier Merleau-Ponty au prisme du miroir lacanien. Putois O. Recherches en psychanalyse, 2013/1 n° 15, p. 60-70.

Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding. Miermont A, Waharte F, Hu S, McClean MN, Bottani S, Léon S, Hersen P. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5725-30. doi: 10.1073/pnas.1215367110. Epub 2013 Mar 14.

Involvement of the Wnt/β-catenin pathway in neurectoderm architecture in Platynereis dumerilii. Demilly A, Steinmetz P, Gazave E, Marchand L, Vervoort M. Nat Commun. 2013; 4:1915. doi: 10.1038/ncomms2915.

Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? Noatynska A, Tavernier N, Gotta M, Pintard L. Open Biol. 2013 Aug 7; 3(8):130083. doi: 10.1098/rsob.130083.

Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA. Adam S, Polo SE, Almouzni G. Cell. 2013 Sep 26; 155(1):94-106. doi: 10.1016/j.cell.2013.08.029.

Posterior elongation in the annelid Platynereis dumerilii involves stem cells molecularly related to primordial germ cells. Gazave E, Béhague J, Laplane L, Guillou A, Préau L, Demilly A, Balavoine G, Vervoort M. Dev Biol. 2013 Oct 1;382(1):246-67. doi: 10.1016/j.ydbio.2013.07.013. Epub 2013 Jul 25.

* «Entretien avec Jocelyn Benoist» De la transmission de la tradition à la grammaire de l’identité. Benoist J, Putois O. Recherches en psychanalyse, 2013/2 n° 16, p. 156-165

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. Baba K, Benleulmi-Chaachoua A, Journé AS, Kamal M, Guillaume JL, Dussaud S, Gbahou F, Yettou K, Liu C, Contreras-Alcantara S, Jockers R, Tosini G. Sci Signal. 2013 Oct 8;6(296). doi: 10.1126/scisignal.2004302.

mRNA nuclear export in yeast. Niño CA, Hérissant L, Babour A, Dargemont C. Chem Rev. 2013 Nov 13;113(11):8523-45. doi: 10.1021/cr400002g. Epub 2013 Jun 3.

*§ H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1. Monnier P, Martinet C, Pontis J, Stancheva I, Ait-Si-Ali S, Dandolo L. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20693-8. doi: 10.1073/pnas.1310201110. Epub 2013 Dec 2.

*Le parricide originaire fait-il partie du fond inné de l’espèce humaine ? Une note épistémologique. Putois O. Revue Française de Psychanalyse, vol. 77, 2013/5, p. 1597-1599.

Le père : un héritage archaïque ? Villa F. Revue française de psychanalyse, vol. 77, 2013/5, p. 1381-1452

À lire aussi

2022 Transition call

2022 Transition call

– CLOSED – Annual Transition call: it aims at financing the end of a Ph.D. (4th year) or a transition phase between the Ph.D. and a postdoc in a different lab to finalize the project and any publications. Find the eligibility...

Pint of Science festival 2022

Pint of Science festival 2022

The Labex Who Am I? is partnering with the Faculty of Sciences of the Université Paris Cité and the École Universitaire Génétique et Épigénétique Nouvelle École (EUR GENE), to offer six events during the Pint of Science festival 2022. © Pint of...